English: Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme).
1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) subunits. The NAM subunits have short peptide chains attached to them. (The exact composition of these can vary. The proximal alanine is usually L-ala and the distal two are usually D-ala.) These chains, in turn, are bound to chains of 5 glycine residues that will be used in cross-linking.
2. The PBP forms a bond with the peptide side chain at the second most distal alanine residue. This displaces the most distal alanine residue.
3. Another strand of bacterial cell wall arrives. The free end of one of the pentaglycine chains displaces the PBP and forms a bond with the terminal alanine on the other strand.
4. After being displaced, the PBP diffuses away.
5. The formation of one cross-link is complete.
วันที่
แหล่งที่มา
งานของตัว
ผู้สร้างสรรค์
Mcstrother
เวอร์ชันอื่น
[แก้ไข]
Cross-linking of bacteria cell wall with no antibiotics.
Action of penicillin
Resistance to penicillin via modified cross-linking enzyme.
Action of vancomycin and resistance via alteration of peptide side-chains.
{{Information |Description ={{en|1=Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme). 1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-ace
ไฟล, catalysis, ไฟล, ประว, ไฟล, หน, าท, ภาพน, การใช, ไฟล, วนกลาง, อม, ลเก, ยวก, บภาพขนาดของต, วอย, าง, ของไฟล, กเซล, ความละเอ, ยดอ, กเซล, กเซล, กเซล, กเซล, กเซล, กเซล, ภาพท, ความละเอ, ยดส, งกว, 8206, ไฟล, กเซล, ขนาดไฟล, เมกะไบต, ปภาพหร, อไฟล, เส, ยงน, นฉบ, บอย. ifl prawtiifl hnathimiphaphni karichiflswnklang khxmulekiywkbphaphkhnadkhxngtwxyang PNG nikhxngifl SVG ni 437 600 phikesl khwamlaexiydxun 175 240 phikesl 350 480 phikesl 560 768 phikesl 746 1 024 phikesl 1 492 2 048 phikesl 1 142 1 567 phikesl duphaphthimikhwamlaexiydsungkwa 8206 ifl SVG 1 142 1 567 phikesl khnadifl 1 44 emkaibt rupphaphhruxiflesiyngni tnchbbxyuthi khxmmxns raylaexiyddanlang epnkhxkhwamthiaesdngphlcak ifltnchbbinkhxmmxns khxmmxnsepnewbistinokhrngkarsahrbekbrwbrwmsuxesri thi khunsamarthchwyid khwamyx khaxthibayPBP catalysis svg English Diagram depicting formation of cross links in the bacterial cell wall by a penicillin binding protein PBP an enzyme 1 The bacterial cell wall consists of strands of repeating N acetylglucosamine NAG and N acetylmuramic acid NAM subunits The NAM subunits have short peptide chains attached to them The exact composition of these can vary The proximal alanine is usually L ala and the distal two are usually D ala These chains in turn are bound to chains of 5 glycine residues that will be used in cross linking 2 The PBP forms a bond with the peptide side chain at the second most distal alanine residue This displaces the most distal alanine residue 3 Another strand of bacterial cell wall arrives The free end of one of the pentaglycine chains displaces the PBP and forms a bond with the terminal alanine on the other strand 4 After being displaced the PBP diffuses away 5 The formation of one cross link is complete wnthi 6 minakhm ph s 2554aehlngthima ngankhxngtwphusrangsrrkh Mcstrotherewxrchnxun aekikh Cross linking of bacteria cell wall with no antibiotics Action of penicillin Resistance to penicillin via modified cross linking enzyme Action of vancomycin and resistance via alteration of peptide side chains Spanish version karxnuyatichsiththi khapheca inthanaphuthuxlikhsiththikhxngphaphhruxsuxni xnuyatihichphaphhruxsuxniphayitenguxnikhtxipniiflnixyuphayitsyyaxnuyatkhriexthifkhxmmxns run aesdngthima 3 0 tnchbbkhunsamarth thicaaebngpn thicathasaena aeckcay aelasngngandngklawtxip thicaeriyberiyngihm thicaddaeplngngandngklaw phayitenguxnikhtxipni aesdngthima khuntxngihekiyrtiecakhxngnganxyangehmaasm odyephimlingkipyngsyyaxnuyat aelarabuhakmikarepliynaeplng khunxacthaechnniidinrupaebbidkidtamkhwr aettxngimichinlksnathiaenawaphuihxnuyatsnbsnunkhunhruxkarichngankhxngkhunhttps creativecommons org licenses by 3 0 CC BY 3 0 Creative Commons Attribution 3 0 true truekhabrryayodyyxithyephimkhabrryaythrrthdediywephuxkhyaykhwamwaiflnimixairixethmthiaesdngxyuiniflniprakxbdwyphusrangbangkhathiimmiixethmwikisnethschuxphusrangsrrkh Mcstrotherchuxphuichwikimiediy Mcstrotheryuxaraexl http commons wikimedia org wiki User McstrothersthanalikhsiththimilikhsiththisyyaxnuyatCreative Commons Attribution 3 0 Unported xngkvswnthisrang wnkxtng6 minakhm 2011thimakhxngiflkarsrangdngedimodyphuxpohld prawtiifl khlikwnthi ewlaephuxduiflthipraktinkhnann wnthi ewlarupyxkhnadphuichkhwamehn pccubn02 26 10 knyayn 25541 142 1 567 1 44 emkaibt McstrotherMajor revision Corrected inaccuracies in previous image 11 15 3 phvsphakhm 25541 139 1 062 850 kiolibt McstrotherChanged all fonts to Liberation Sans 10 46 10 emsayn 25541 139 1 062 850 kiolibt McstrotherChanged color of carbohydrate chain 10 30 7 minakhm 25541 139 1 062 835 kiolibt Mcstrother Information Description en 1 Diagram depicting formation of cross links in the bacterial cell wall by a penicillin binding protein PBP an enzyme 1 The bacterial cell wall consists of strands of repeating N acetylglucosamine NAG and N ace hnathimiphaphni hnatxipni oyngmathiphaphni epbthiodiklaekhn karichiflswnklang wikixuntxipniichiflni karichbn en wikipedia org Peptidoglycan User Mcstrother karichbn es wikipedia org Peptidoglucano Staphylococcus aureus Usuario Viascos Taller karichbn fa wikipedia org پپتیدوگلیکان karichbn ga wikipedia org Peiptidigliocan karichbn gl wikipedia org Peptidoglicano Staphylococcus aureus karichbn hu wikipedia org Szerkeszto Alfa ketosav Peptidoglikan karichbn it wikipedia org Peptidoglicano karichbn mk wikipedia org Peptidoglikankhxmulekiywkbphaph phaphnimikhxmulephimetim sungswnihymacakklxngdicitxlhruxsaeknenxrthisamarthekbkhxmuldngklawiwrwmkbphaphid thaphaphnithukprbprungaekikhhruxepliynaeplngcakedim khxmulbangxyangcayngkhngimepliynaeplngehmuxnphaphthithukprbprungaekikhnnchuxeruxngsnPenicillin binding protein catalysis ekhathungcak https th wikipedia org wiki ifl PBP catalysis svg, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
