English: Enzymes, their cellular location, substrates and products in human steroidogenesis.
Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids. White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see structural formula.
HSD: Hydroxysteroid dehydrogenase
References:
Boron WF, Boulpaep EL (พ.ศ. 2546) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.
Further reading:
Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.
See also:
Wikiversity:Diagram of the pathways of human steroidogenesis
Polski: Enzymy biorące udział w steroidogenezie.
Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.
HSD: Dehydrogenaza hydroksysteroidu
Русский: Ферменты, участвующие в стероидогенезе человека, с указанием субстратов и продуктов, а также локализации их активности. Происходящие изменения в структуре молекул отмечены белыми кружочками. По сборнику "Медицинская физиология" (Walter F. Boron, Emile L. Boulpaep, 2003 год).
Häggström M, Richfield D (2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine1 (1). DOI:10.15347/wjm/2014.005. ISSN 20024436.
ผู้สร้างสรรค์
David Richfield (Slashme) and Mikael Häggström. Derived from previous version by Hoffmeier and Settersr.
In external use, this diagram may be cited as:
(2014). "Diagram of the pathways of human steroidogenesis". WikiJournal of Medicine1 (1). DOI:10.15347/wjm/2014.005. ISSN 20018762.
เวอร์ชันอื่น
แก้ไข
Original. See also Evolution. Raster (.png) version is available
A short flashback of some milestones the evolution of the picture, demonstrating the power of free licensing where anybody can contribute to making things better.
1. (March 2007) Previous image by Stannered.
4. (August 2008) Vector (.svg) version by Slashme.
2. (July 2007) Molecular structures added by Hoffmeier and Settersr.
5. (March 2009) Expansion, grouping, addition of enzyme localization, numbering of cholesterol and coloring by Mikael Häggström.
3. (November 2007) Organization and addition of enzymes by Mikael Häggström.
ไฟล, steroidogenesis, ไฟล, ประว, ไฟล, หน, าท, ภาพน, การใช, ไฟล, วนกลาง, อม, ลเก, ยวก, บภาพขนาดของต, วอย, าง, ของไฟล, กเซล, ความละเอ, ยดอ, กเซล, กเซล, กเซล, กเซล, กเซล, กเซล, ภาพท, ความละเอ, ยดส, งกว, 8206, ไฟล, กเซล, ขนาดไฟล, โลไบต, เรนเดอร, ภาพน, ใน, เครน, บา. ifl prawtiifl hnathimiphaphni karichiflswnklang khxmulekiywkbphaphkhnadkhxngtwxyang PNG nikhxngifl SVG ni 676 600 phikesl khwamlaexiydxun 270 240 phikesl 541 480 phikesl 865 768 phikesl 1 154 1 024 phikesl 2 308 2 048 phikesl 1 245 1 105 phikesl duphaphthimikhwamlaexiydsungkwa 8206 ifl SVG 1 245 1 105 phikesl khnadifl 224 kiolibt ernedxrphaphniin yuekhrn uk bask eu phasaodypriyay rupphaphhruxiflesiyngni tnchbbxyuthi khxmmxns raylaexiyddanlang epnkhxkhwamthiaesdngphlcak ifltnchbbinkhxmmxns khxmmxnsepnewbistinokhrngkarsahrbekbrwbrwmsuxesri thi khunsamarthchwyid enuxha 1 khwamyx 1 1 Translations 2 Evolution 3 karxnuyatichsiththi khwamyx khaxthibaySteroidogenesis svg English Enzymes their cellular location substrates and products in human steroidogenesis Shown also is the major classes of steroid hormones progestagens mineralocorticoids glucocorticoids androgens and estrogens However they partly overlap e g mineralocorticoids and glucocorticoids White circles indicate changes in molecular structure compared with precursors For more information on interpretation of molecular structures see structural formula HSD Hydroxysteroid dehydrogenaseReferences Boron WF Boulpaep EL ph s 2546 Medical Physiology A Cellular And Molecular Approach Elsevier Saunders pp page 1 300 ISBN 1 4160 2328 3 For the absence of conversion of corticosterone to cortisol Steroid hormone biosynthesis Reference pathway KO KEGG Kyoto Encyclopedia of Genes and Genomes Kyoto University Bioinformatics Center 1 November 2013 There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21 OH steroids are poor substrates for 17 alpha hydroxylase Further reading Hanukoglu I 1992 Steroidogenic enzymes structure function and role in regulation of steroid hormone biosynthesis The Journal of Steroid Biochemistry and Molecular Biology 43 8 779 804 DOI 10 1016 0960 0760 92 90307 5 PMID 22217824 Payne AH Hales DB 2004 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Endocrine Reviews 25 6 947 70 DOI 10 1210 er 2003 0030 PMID 15583024 See also Wikiversity Diagram of the pathways of human steroidogenesis Polski Enzymy biorace udzial w steroidogenezie Uwagi W miejscu gdzie stereochemia nie jest wyswietlana jest taka sama jak dla Cholesterol lub w pokazanej powyzej grupie HSD Dehydrogenaza hydroksysteroidu Russkij Fermenty uchastvuyushie v steroidogeneze cheloveka s ukazaniem substratov i produktov a takzhe lokalizacii ih aktivnosti Proishodyashie izmeneniya v strukture molekul otmecheny belymi kruzhochkami Po sborniku Medicinskaya fiziologiya Walter F Boron Emile L Boulpaep 2003 god 日本語 この図はヒトのステロイドホルモン生成における酵素と酵素が存在する細胞器官 基質ならびに生成物の全体図である またこの図は コレステロールから プロゲステロン 鉱質コルチコイド 糖質コルチコイド そしてアンドロゲンおよびエストロゲンに至る主要なステロイドを記述している 図に示すとおりそれぞれ 生合成の過程で オーバーラップするものである 図中 白い円で囲んだところは基質と比較した分子構造の変化した箇所を示す なお HSD は ヒドロキシステロイドデヒドロゲナーゼを表す wnthi 28 minakhm ph s 2552aehlngthima Haggstrom M Richfield D 2014 Diagram of the pathways of human steroidogenesis WikiJournal of Medicine 1 1 DOI 10 15347 wjm 2014 005 ISSN 20024436 phusrangsrrkh David Richfield Slashme and Mikael Haggstrom Derived from previous version by Hoffmeier and Settersr In external use this diagram may be cited as 2014 Diagram of the pathways of human steroidogenesis WikiJournal of Medicine 1 1 DOI 10 15347 wjm 2014 005 ISSN 20018762 ewxrchnxun aekikh Original See also Evolution Raster png version is available Translations 中文 國語 Russkij Galego العربية polski German 日本語SVG genesisInfoField sxrsokhdkhxng SVG nitrwcsxbthuktxngaelw iflphaphkrafiksewketxrni srangkhunodyich Inkscape The chemistry symbols of this structural formula are drawn using the path text method nikhuxphaphkhdsrrinwikiphiediyphasaxngkvs 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Commons Attribution Share Alike 3 0 true truekhabrryayodyyxithyephimkhabrryaythrrthdediywephuxkhyaykhwamwaiflnimixairxngkvsA schematic diagram showing the chemicals enzymes and locations of the human steroidogenesis pathways xngkvs shrachxanackrA schematic diagram showing the chemicals enzymes and locations of the human steroidogenesis pathways ixethmthiaesdngxyuiniflniprakxbdwysthanalikhsiththimilikhsiththisyyaxnuyatCreative Commons Attribution ShareAlike 3 0 Unported xngkvsGNU Free Documentation License version 1 2 or later xngkvswnthisrang wnkxtng28 minakhm 2009MIME type xngkvsimage svg xml prawtiifl khlikwnthi ewlaephuxduiflthipraktinkhnann lasud ekasud du ihmkwa 10 ekakwa 10 10 20 50 100 250 500 wnthi ewlarupyxkhnadphuichkhwamehn pccubn17 52 28 tulakhm 25651 245 1 105 224 kiolibt Uxue GarciaFile uploaded using svgtranslate tool https svgtranslate toolforge org Added translation for eu 22 58 8 emsayn 25631 245 1 105 198 kiolibt AtaFile uploaded using svgtranslate tool https tools wmflabs org svgtranslate Added translation for uk 22 54 8 emsayn 25631 245 1 105 187 kiolibt AtaFile uploaded using svgtranslate tool https tools wmflabs org svgtranslate Added translation for uk 22 12 13 minakhm 25561 245 1 105 133 kiolibt SlashmeRemoved arrow from Corticosterone to Cortisol via CYP17A1 see http www genome jp kegg bin show pathway ko00140 C02140 23 15 9 krkdakhm 25551 245 1 105 133 kiolibt Mikael HaggstromAddition and correction of stereochemistries at positions 11 and 17 11 24 9 krkdakhm 25551 245 1 105 127 kiolibt Mikael HaggstromAdded stereochemistries removed redundant white circle at cortisol renamed 21 alpha hydroxylase to simply 21 hydroxylase 12 15 13 thnwakhm 25541 245 1 105 114 kiolibt SlashmeAlign some text and arrows for neatness 039 sake 11 56 13 thnwakhm 25541 245 1 105 114 kiolibt SlashmeFixed reaction scheme corticosterone doesn 039 t go to cortisol Karl and Lindie why didn 039 t you fix it when you first found out Tsk tsk 19 58 8 phvsphakhm 25531 245 1 105 114 kiolibt Mikael Haggstromminor move of 5 a reductase 19 56 8 phvsphakhm 25531 245 1 105 114 kiolibt Mikael Haggstromminor renaming of 3 beta HSD lasud ekasud du ihmkwa 10 ekakwa 10 10 20 50 100 250 500 hnathimiphaphni hnatxipni oyngmathiphaphni ethsothsetxorn karichiflswnklang wikixuntxipniichiflni karichbn af wikipedia org 3b Hidroksisteroieddehidrogenase karichbn ar wikipedia org ويكيبيديا ورشة الصور أرشيف 22 karichbn ast wikipedia org Testosterona karichbn bn wikipedia org ক ল স ট রল এস ট র ড ওল karichbn bs wikipedia org Estriol Estron Steroidogeneza Estradiol Zuto tijelo Steroidni hormoni Aldosteron Kortizol Dehidroepiandrosteron Androgen Spolni hormon Androstendion Pregnenolon Androstendiol 17a Hidroksipregnenolon 17a Hidroksiprogesteron Kongenitalna nadbubrezna hiperplazija CYP11B1 CYP21A2 Nedostatak 21 hidroksilaze Citohrom P450 karichbn ca wikipedia org Estrogen Glucocorticoide Hormona esteroidal Aromatasa Androgen Progesterona Androstendiona Estrona Estriol Citocrom p450 Corticosterona karichbn da wikipedia org Testosteron Steroid Steroidhormon karichbn de wikipedia org Benutzer W S Herrmann Mannerdammerung karichbn de wikibooks org Benutzer OnkelDagobert Wikilinks Innere Medizin karichbn el wikipedia org Oistradiolh karichbn en wikipedia org Cholesterol Dehydroepiandrosterone Estrogen Testosterone Progesterone Steroid Estradiol dukarichthwolkephimetimkhxngiflnikhxmulekiywkbphaph phaphnimikhxmulephimetim sungswnihymacakklxngdicitxlhruxsaeknenxrthisamarthekbkhxmuldngklawiwrwmkbphaphid thaphaphnithukprbprungaekikhhruxepliynaeplngcakedim khxmulbangxyangcayngkhngimepliynaeplngehmuxnphaphthithukprbprungaekikhnnkhwamkwang1244 76khwamsung1105 ekhathungcak https th wikipedia org wiki ifl Steroidogenesis svg, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
