• negative regulation of peptidase activity • response to UV • regulation of proteolysis • negative regulation of endopeptidase activity • negative regulation of keratinocyte apoptotic process • regulation of keratinocyte differentiation
Abts HF, Breuhahn K, Michel G, Kohrer K, Esser P, Ruzicka T (Oct 1997). "Analysis of UVB-modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction". Photochem Photobiol. 66 (3): 363–7. doi:10.1111/j.1751-1097.1997.tb03159.x. PMID 9297979.
Abts HF, Welss T, Mirmohammadsadegh A, Kohrer K, Michel G, Ruzicka T (Nov 1999). "Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family". J Mol Biol. 293 (1): 29–39. doi:10.1006/jmbi.1999.3159. PMID 10512713.
"Entrez Gene: SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13".
แหล่งข้อมูลอื่น
Spring P, Nakashima T, Frederick M, และคณะ (1999). "Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q". Biochem. Biophys. Res. Commun. 264 (1): 299–304. doi:10.1006/bbrc.1999.1453. PMID 10527881.
Nakashima T, Pak SC, Silverman GA, และคณะ (2000). "Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells". Biochim. Biophys. Acta. 1492 (2–3): 441–6. doi:10.1016/s0167-4781(00)00100-7. PMID 11004515.
Abts HF, Welss T, Scheuring S, และคณะ (2001). "Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis". DNA Cell Biol. 20 (3): 123–31. doi:10.1089/104454901300068924. PMID 11313015.
Strausberg RL, Feingold EA, Grouse LH, และคณะ (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Jayakumar A, Kang Y, Frederick MJ, และคณะ (2003). "Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis". Arch. Biochem. Biophys. 409 (2): 367–74. doi:10.1016/S0003-9861(02)00635-5. PMID 12504904.
Welss T, Sun J, Irving JA, และคณะ (2003). "Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis". Biochemistry. 42 (24): 7381–9. doi:10.1021/bi027307q. PMID 12809493.
Gerhard DS, Wagner L, Feingold EA, และคณะ (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Moussali H, Bylaite M, Welss T, และคณะ (2005). "Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas". Exp. Dermatol. 14 (6): 420–8. doi:10.1111/j.0906-6705.2005.00300.x. PMID 15885077.
Shellenberger TD, Mazumdar A, Henderson Y, และคณะ (2006). "Headpin: a serpin with endogenous and exogenous suppression of angiogenesis". Cancer Res. 65 (24): 11501–9. doi:10.1158/0008-5472.CAN-05-2262. PMID 16357159.
Bylaite M, Moussali H, Marciukaitiene I, และคณะ (2006). "Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases". Exp. Dermatol. 15 (2): 110–8. doi:10.1111/j.1600-0625.2005.00389.x. PMID 16433682.
serpinb13, เซอร, งกฤษ, serpin, หร, เป, นโปรต, นของมน, ษย, และเป, นโปรต, นสมาช, กลำด, บท, ในเคลดบ, ของมหาวงศ, เซอร, serpin, family, member, กถอดรห, สได, โดยย, บนโครโมโซมค, identifiersaliases, hshur7seq, hur7, pi13, headpin, serpin, family, member, 13external, i. esxrpin bi13 xngkvs Serpin B13 hrux SERPINB13 epnoprtinkhxngmnusy aelaepnoprtinsmachikladbthi 13 inekhldbikhxngmhawngsesxrpin Serpin family B member 13 thukthxdrhsidodyyin SERPINB13 bnokhromosmkhuthi 18 2 3 4 SERPINB13IdentifiersAliasesSERPINB13 HSHUR7SEQ HUR7 PI13 headpin serpin family B member 13External IDsOMIM 604445 HomoloGene 22718 GeneCards SERPINB13RNA expression patternMore reference expression dataGene ontologyMolecular function peptidase inhibitor activity protease binding cysteine type endopeptidase inhibitor activity serine type endopeptidase inhibitor activityCellular component isothphlasum exkososmchnidphaynxkesll niwkhlioxls niwkhlioxphlassum phaynxkesll isotsxl nuclear speck lysosomal lumenBiological process negative regulation of peptidase activity response to UV regulation of proteolysis negative regulation of endopeptidase activity negative regulation of keratinocyte apoptotic process regulation of keratinocyte differentiationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5275n aEnsemblENSG00000197641n aUniProtQ9UIV8n aRefSeq mRNA NM 001307923NM 012397n aRefSeq protein NP 001294852NP 036529NP 001335196NP 001335197NP 001335198NP 001335199n aLocation UCSC n an aPubMed search 1 n aWikidataView Edit Humanduephim aekikhesxrpinxangxing aekikh Human PubMed Reference Abts HF Breuhahn K Michel G Kohrer K Esser P Ruzicka T Oct 1997 Analysis of UVB modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction Photochem Photobiol 66 3 363 7 doi 10 1111 j 1751 1097 1997 tb03159 x PMID 9297979 Abts HF Welss T Mirmohammadsadegh A Kohrer K Michel G Ruzicka T Nov 1999 Cloning and characterization of hurpin protease inhibitor 13 A new skin specific UV repressible serine proteinase inhibitor of the ovalbumin serpin family J Mol Biol 293 1 29 39 doi 10 1006 jmbi 1999 3159 PMID 10512713 Entrez Gene SERPINB13 serpin peptidase inhibitor clade B ovalbumin member 13 aehlngkhxmulxun aekikhSpring P Nakashima T Frederick M aelakhna 1999 Identification and cDNA cloning of headpin a novel differentially expressed serpin that maps to chromosome 18q Biochem Biophys Res Commun 264 1 299 304 doi 10 1006 bbrc 1999 1453 PMID 10527881 Nakashima T Pak SC Silverman GA aelakhna 2000 Genomic cloning mapping structure and promoter analysis of HEADPIN a serpin which is down regulated in head and neck cancer cells Biochim Biophys Acta 1492 2 3 441 6 doi 10 1016 s0167 4781 00 00100 7 PMID 11004515 Abts HF Welss T Scheuring S aelakhna 2001 Sequence organization chromosomal localization and alternative splicing of the human serine protease inhibitor gene hurpin PI13 which is upregulated in psoriasis DNA Cell Biol 20 3 123 31 doi 10 1089 104454901300068924 PMID 11313015 Strausberg RL Feingold EA Grouse LH aelakhna 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Jayakumar A Kang Y Frederick MJ aelakhna 2003 Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin SERPINB13 a kinetic analysis Arch Biochem Biophys 409 2 367 74 doi 10 1016 S0003 9861 02 00635 5 PMID 12504904 Welss T Sun J Irving JA aelakhna 2003 Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet induced apoptosis Biochemistry 42 24 7381 9 doi 10 1021 bi027307q PMID 12809493 Gerhard DS Wagner L Feingold EA aelakhna 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Moussali H Bylaite M Welss T aelakhna 2005 Expression of hurpin a serine proteinase inhibitor in normal and pathological skin overexpression and redistribution in psoriasis and cutaneous carcinomas Exp Dermatol 14 6 420 8 doi 10 1111 j 0906 6705 2005 00300 x PMID 15885077 Shellenberger TD Mazumdar A Henderson Y aelakhna 2006 Headpin a serpin with endogenous and exogenous suppression of angiogenesis Cancer Res 65 24 11501 9 doi 10 1158 0008 5472 CAN 05 2262 PMID 16357159 Bylaite M Moussali H Marciukaitiene I aelakhna 2006 Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases Exp Dermatol 15 2 110 8 doi 10 1111 j 1600 0625 2005 00389 x PMID 16433682 thankhxmulxxniln MEROPS sahrbeppthieds aelasarybyngeppthieds I04 017 SERPINB13 protein human inhxsmudaephthysastraehngchatixemrikn sahrbhwkhxenuxhathangkaraephthy MeSH bthkhwamnirwbrwmkhxmulcakhxsmudaephthysastraehngchatixemrikn sungcdepnsatharnsmbti bthkhwamniekiywkhxngkbyinbnokhromosmkhuthi 18 aelaepnbthkhwamthikalngrxephimetimkhxmul khunsamarthchwyephimetimkhxmulinswnniidekhathungcak https th wikipedia org w index php title SERPINB13 amp oldid 9088730, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
