• positive regulation of transcription regulatory region DNA binding • skeletal system development • positive regulation of glucose import • movement of cell or subcellular component • muscle organ development • positive regulation of Ras protein signal transduction • response to heat • positive regulation of cardiac muscle hypertrophy • positive regulation of smooth muscle cell migration • การถ่ายแบบดีเอ็นเอ • positive regulation of insulin-like growth factor receptor signaling pathway • phosphatidylinositol 3-kinase signaling • positive regulation of DNA binding • Ras protein signal transduction • cell population proliferation • positive regulation of mitotic nuclear division • positive regulation of trophectodermal cell proliferation • positive regulation of glycogen biosynthetic process • positive regulation of fibroblast proliferation • ERK1 and ERK2 cascade • negative regulation of extrinsic apoptotic signaling pathway • cell activation • negative regulation of oocyte development • positive regulation of transcription, DNA-templated • bone mineralization involved in bone maturation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of MAPK cascade • proteoglycan biosynthetic process • positive regulation of activated T cell proliferation • positive regulation of epithelial cell proliferation • negative regulation of release of cytochrome c from mitochondria • protein stabilization • myotube cell development • positive regulation of DNA replication • myoblast proliferation • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • positive regulation of protein secretion • positive regulation of glycoprotein biosynthetic process • การควบคุมการแสดงออกของยีน • phosphatidylinositol-mediated signaling • positive regulation of smooth muscle cell proliferation • cellular protein metabolic process • muscle hypertrophy • protein kinase B signaling • regulation of multicellular organism growth • positive regulation of cell migration • platelet degranulation • positive regulation of calcineurin-NFAT signaling cascade • positive regulation of phosphatidylinositol 3-kinase signaling • myoblast differentiation • glycolate metabolic process • positive regulation of glycolytic process • negative regulation of smooth muscle cell apoptotic process • การถ่ายโอนสัญญาณ • positive regulation of transcription by RNA polymerase II • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of cell population proliferation • positive regulation of osteoblast differentiation • activation of protein kinase B activity • insulin-like growth factor receptor signaling pathway • การควบคุมเชิงลบต่ออะพอพโทซิส • positive regulation of tyrosine phosphorylation of STAT protein • regulation of signaling receptor activity • positive regulation of gene expression • negative regulation of gene expression • cellular response to amyloid-beta • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of tumor necrosis factor production • negative regulation of neuroinflammatory response • negative regulation of amyloid-beta formation
↑ GRCh38: Ensembl release 89: ENSG00000017427 - Ensembl, May 2017
"Human PubMed Reference:".
Höppener JW, de Pagter-Holthuizen P, Geurts van Kessel AH, Jansen M, Kittur SD, Antonarakis SE, Lips CJ, Sussenbach JS (1985). "The human gene encoding insulin-like growth factor I is located on chromosome 12". Hum. Genet. 69 (2): 157–60. doi:10.1007/BF00293288. PMID 2982726. S2CID 5825276.
Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL (1983). "Sequence of cDNA encoding human insulin-like growth factor I precursor". Nature. 306 (5943): 609–11. Bibcode:1983Natur.306..609J. doi:10.1038/306609a0. PMID 6358902. S2CID 4336584.
Rinderknecht E, Humbel RE (1978). "The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin". J Biol Chem. 253 (8): 2769–2776. PMID 632300.
Decourtye L, Mire E, Clemessy M, Heurtier V, Ledent T, Robinson IC, Mollard P, Epelbaum J, Meaney MJ, Garel S, Le Bouc Y, Kappeler L (2017). "IGF-1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice". PLOS ONE. 12 (1): e0170083. Bibcode:2017PLoSO..1270083D. doi:10.1371/journal.pone.0170083. PMC5226784. PMID 28076448.
insulin, like, growth, factor, บทความน, อเป, นภาษาอ, งกฤษ, เน, องจากย, งไม, อภาษาไทยท, กระช, เหมาะสม, ไม, ปรากฏคำอ, านท, แน, หร, อไม, ปรากฏคำแปลท, ใช, ในทางว, ชาการ, หร, อเร, ยกว, somatomedin, เป, นฮอร, โมนท, โครงสร, างโมเลก, ลคล, ายเค, ยงก, บอ, นซ, บทบาทสำค, . bthkhwamnimichuxepnphasaxngkvs enuxngcakyngimmichuxphasaithythikrachb ehmaasm impraktkhaxanthiaenchd hruximpraktkhaaeplthiichinthangwichakarInsulin like growth factor 1 IGF 1 hruxeriykwa somatomedin C epnhxromnthimiokhrngsrangomelkulkhlayekhiyngkbxinsulin mibthbathsakhyinkaretibotkhxngedkaelakrabwnkarxanabxlikinphuihyIGF1Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1B9G 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSR 2GF1 3GF1 3LRI 1BQT 4XSSIdentifiersAliasesIGF1 IGF I IGF1A IGFI MGF insulin like growth factor 1 IGFExternal IDsOMIM 147440 HomoloGene 515 GeneCards IGF1Gene location Human Chr Chromosome 12 human 1 Band12q23 2Start102 395 874 bp 1 End102 481 744 bp 1 RNA expression patternMore reference expression dataGene ontologyMolecular function hormone activity insulin receptor binding growth factor activity integrin binding GO 0001948 karcbkboprtin insulin like growth factor receptor bindingCellular component extracellular region exocytic vesicle insulin like growth factor binding protein complex platelet alpha granule lumen insulin like growth factor ternary complex alphav beta3 integrin IGF 1 IGF1R complex eyuxhumesll phaynxkesllBiological process positive regulation of transcription regulatory region DNA binding skeletal system development positive regulation of glucose import movement of cell or subcellular component muscle organ development positive regulation of Ras protein signal transduction response to heat positive regulation of cardiac muscle hypertrophy positive regulation of smooth muscle cell migration karthayaebbdiexnex positive regulation of insulin like growth factor receptor signaling pathway phosphatidylinositol 3 kinase signaling positive regulation of DNA binding Ras protein signal transduction cell population proliferation positive regulation of mitotic nuclear division positive regulation of trophectodermal cell proliferation positive regulation of glycogen biosynthetic process positive regulation of fibroblast proliferation ERK1 and ERK2 cascade negative regulation of extrinsic apoptotic signaling pathway cell activation negative regulation of oocyte development positive regulation of transcription DNA templated bone mineralization involved in bone maturation positive regulation of peptidyl tyrosine phosphorylation positive regulation of MAPK cascade proteoglycan biosynthetic process positive regulation of activated T cell proliferation positive regulation of epithelial cell proliferation negative regulation of release of cytochrome c from mitochondria protein stabilization myotube cell development positive regulation of DNA replication myoblast proliferation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration positive regulation of protein secretion positive regulation of glycoprotein biosynthetic process karkhwbkhumkaraesdngxxkkhxngyin phosphatidylinositol mediated signaling positive regulation of smooth muscle cell proliferation cellular protein metabolic process muscle hypertrophy protein kinase B signaling regulation of multicellular organism growth positive regulation of cell migration platelet degranulation positive regulation of calcineurin NFAT signaling cascade positive regulation of phosphatidylinositol 3 kinase signaling myoblast differentiation glycolate metabolic process positive regulation of glycolytic process negative regulation of smooth muscle cell apoptotic process karthayoxnsyyan positive regulation of transcription by RNA polymerase II positive regulation of cell growth involved in cardiac muscle cell development positive regulation of cell population proliferation positive regulation of osteoblast differentiation activation of protein kinase B activity insulin like growth factor receptor signaling pathway karkhwbkhumechinglbtxxaphxphothsis positive regulation of tyrosine phosphorylation of STAT protein regulation of signaling receptor activity positive regulation of gene expression negative regulation of gene expression cellular response to amyloid beta positive regulation of vascular associated smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process negative regulation of interleukin 1 beta production negative regulation of tumor necrosis factor production negative regulation of neuroinflammatory response negative regulation of amyloid beta formationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez3479n aEnsemblENSG00000017427n aUniProtP05019n aRefSeq mRNA NM 000618NM 001111283NM 001111284NM 001111285n aRefSeq protein NP 000609NP 001104753NP 001104754NP 001104755n aLocation UCSC Chr 12 102 4 102 48 Mbn aPubMed search 2 n aWikidataView Edit HumanIGF 1 epnoprtinthiinmnusysrangkhuncakyin IGF1 3 4 IGF 1 prakxbdwykrdxamioncanwn 70 xninsayediywaelamiphnthaidslifdsamphnthaphayinomelkub IGF 1 mimwlomelkulthi 7 649 dxltn 5 IGF 1 phlitkhunhlk intbphayitkarkratunkhxngokrthhxromn GH ody IGF 1 swnihycacbkbhnunginhkchnidkhxng binding proteins IGF BP ody IGFBP 1 khwbkhumodyxinsulin IGF 1 phlitkhunmatlxdchiwit aetxtrakarphlit IGF 1 sungsudxyurahwangkarerimtnwyrun 6 sarethiybekhiyng IGF 1 sngekhraahchux mecasermin miichinikephuxrksakarkhadkarecriyetibot 7 duephim aekikhosmaothphxsxangxing aekikh 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000017427 Ensembl May 2017 Human PubMed Reference Hoppener JW de Pagter Holthuizen P Geurts van Kessel AH Jansen M Kittur SD Antonarakis SE Lips CJ Sussenbach JS 1985 The human gene encoding insulin like growth factor I is located on chromosome 12 Hum Genet 69 2 157 60 doi 10 1007 BF00293288 PMID 2982726 S2CID 5825276 Jansen M van Schaik FM Ricker AT Bullock B Woods DE Gabbay KH Nussbaum AL Sussenbach JS Van den Brande JL 1983 Sequence of cDNA encoding human insulin like growth factor I precursor Nature 306 5943 609 11 Bibcode 1983Natur 306 609J doi 10 1038 306609a0 PMID 6358902 S2CID 4336584 Rinderknecht E Humbel RE 1978 The amino acid sequence of human insulin like growth factor I and its structural homology with proinsulin J Biol Chem 253 8 2769 2776 PMID 632300 Decourtye L Mire E Clemessy M Heurtier V Ledent T Robinson IC Mollard P Epelbaum J Meaney MJ Garel S Le Bouc Y Kappeler L 2017 IGF 1 Induces GHRH Neuronal Axon Elongation during Early Postnatal Life in Mice PLOS ONE 12 1 e0170083 Bibcode 2017PLoSO 1270083D doi 10 1371 journal pone 0170083 PMC 5226784 PMID 28076448 Keating GM 2008 Mecasermin BioDrugs 22 3 177 88 doi 10 2165 00063030 200822030 00004 PMID 18481900 aehlngkhxmulxun aekikhInsulin Like Growth Factor I inhxsmudaephthysastraehngchatixemrikn sahrbhwkhxenuxhathangkaraephthy MeSH khxmulechingokhrngsrangthnghmdkhxng UniProt P05019 Insulin like growth factor I samarthekhathungidinthnakharkhxmuloprtinkhxng PDBe KB aemaebb Growth factors aemaebb Hormones aemaebb Neurotrophic factors aemaebb Growth factor receptor modulators aemaebb Signaling peptide protein receptor modulators ekhathungcak https th wikipedia org w index php title Insulin like growth factor 1 amp oldid 9315951, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
