• iron ion binding • arachidonic acid epoxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • oxidoreductase activity • coumarin 7-hydroxylase activity • steroid hydroxylase activity
• steroid metabolic process • exogenous drug catabolic process • epoxygenase P450 pathway • coumarin catabolic process • drug metabolic process • coumarin metabolic process • organic acid metabolic process • xenobiotic metabolic process
↑ GRCh38: Ensembl release 89: ENSG00000255974 - Ensembl, May 2017
"Human PubMed Reference:".
↑ "Entrez Gene: CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6".
↑ National Center for Biotechnology Information (April 8, 2018). "CYP2A6 cytochrome P450 family 2 subfamily A member 6 [ Homo sapiens (human) ]". U.S. National Library of Medicine. จากแหล่งเดิมเมื่อ 2016-10-01. สืบค้นเมื่อ April 12, 2018.
Hellmold H, Magnusson M, Pelto-Huikko M, Rylander T, Gustafsson J, Warner M. (1998). "Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal rat breast" (PDF). Mol Pharmacol. 53 (3): 475–82. PMID 9495814. Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
National Center for Biotechnology Information (March 13, 2018). . U.S. National Library of Medicine. คลังข้อมูลเก่า เก็บจาก แหล่งเดิม เมื่อ April 12, 2018. สืบค้นเมื่อ April 12, 2018.
↑ Weizmann Institute of Science (2018). . คลังข้อมูลเก่า เก็บจาก แหล่งเดิม เมื่อ January 3, 2018. สืบค้นเมื่อ April 12, 2018.
A.B. RENWICK, P. S. Watts, R. J. Edwards, P. T. Barton, I.Guyonnet, R. J. Price, J. M. Tredger, O. Pelkonen, A. R. Boobis, and B. G. Lake (2000). "Differential Maintenance of Cytochrome P450 Enzymes in Cultured Precision-cut Human Liver Slices" (PDF). The American Society for Pharmacology and Experimental Therapeutics. 28 (10): 1202–9. PMID 10997941. Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
El Sayed, YM; Sadée, W (1983). "Metabolic activation of R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes". Cancer Research. 43 (9): 4039–44. PMID 6409396.
Nakayama, T; Noguchi, S (January 2010). "Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan" (PDF). The Oncologist. 15 (1): 26–36. doi:10.1634/theoncologist.2009-0255. PMC3227888. PMID 20080863.
Matt P, van Zwieten-Boot B, Calvo Rojas G, Ter Hofstede H, Garcia-Carbonero R, Camarero J, Abadie E, Pignatti F (October 2011). "The European Medicines Agency review of Tegafur/Gimeracil/Oteracil (Teysuno™) for the treatment of advanced gastric cancer when given in combination with cisplatin: summary of the Scientific Assessment of the Committee for medicinal products for human use (CHMP)" (PDF). The Oncologist. 16 (10): 1451–1457. doi:10.1634/theoncologist.2011-0224. PMC3228070. PMID 21963999.CS1 maint: uses authors parameter (link)
↑ Lacy CF, Armstrong LL, Goldman MP, Lance LL (2007). Cytochrome P450 Enzymes: Substrates, Inhibitors, and Inducers. Hudson, OH: LexiComp Inc. pp. 1899–1912.CS1 maint: uses authors parameter (link)
Wen X, Wang JS, Neuvonen PJ, Backman JT (2002). "Isoniazid is a mechanism-based inhibitor of cytochrome P450 1A2, 2A6, 2C19 and 3A4 isoforms in human liver microsomes". Eur. J. Clin. Pharmacol. 57 (11): 799–804. doi:10.1007/s00228-001-0396-3. PMID 11868802.CS1 maint: uses authors parameter (link)
Siu EC, Tyndale RF (2008). "Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice". J. Pharmacol. Exp. Ther. 324 (3): 992–9. doi:10.1124/jpet.107.133900. PMID 18065502.CS1 maint: uses authors parameter (link)
แหล่งข้อมูลอื่น
Pelkonen O, Rautio A, Raunio H, Pasanen M (2000). "CYP2A6: a human coumarin 7-hydroxylase". Toxicology. 144 (1–3): 139–47. doi:10.1016/S0300-483X(99)00200-0. PMID 10781881.CS1 maint: uses authors parameter (link)
Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis". Pharmacogenetics. 5 (Special Issue): S123–8. doi:10.1097/00008571-199512001-00013. PMID 7581481.CS1 maint: uses authors parameter (link)
Smith G, Stubbins MJ, Harries LW, Wolf CR (1999). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.CS1 maint: uses authors parameter (link)
Pelkonen O, Rautio A, Raunio H, Pasanen M (2000). "CYP2A6: a human coumarin 7-hydroxylase". Toxicology. 144 (1–3): 139–47. doi:10.1016/S0300-483X(99)00200-0. PMID 10781881.CS1 maint: uses authors parameter (link)
Tyndale RF, Sellers EM (2002). "Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior". Therapeutic drug monitoring. 24 (1): 163–71. doi:10.1097/00007691-200202000-00026. PMID 11805739.CS1 maint: uses authors parameter (link)
Kamataki T, Fujieda M, Kiyotani K และคณะ (2005). "Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco-related cancer risk". Biochem. Biophys. Res. Commun. 338 (1): 306–10. doi:10.1016/j.bbrc.2005.08.268. PMID 16176798.CS1 maint: uses authors parameter (link)
Maurice M, Emiliani S, Dalet-Beluche I และคณะ (1991). "Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes". Eur. J. Biochem. 200 (2): 511–7. doi:10.1111/j.1432-1033.1991.tb16212.x. PMID 1889415.CS1 maint: uses authors parameter (link)
Yun CH, Shimada T, Guengerich FP (1991). "Purification and characterization of human liver microsomal cytochrome P-450 2A6". Mol. Pharmacol. 40 (5): 679–85. PMID 1944238.CS1 maint: uses authors parameter (link)
Yamano S, Tatsuno J, Gonzalez FJ (1990). "The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes". Biochemistry. 29 (5): 1322–9. doi:10.1021/bi00457a031. PMID 2322567.CS1 maint: uses authors parameter (link)
Miles JS, Bickmore W, Brook JD และคณะ (1989). "Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity". Nucleic Acids Res. 17 (8): 2907–17. doi:10.1093/nar/17.8.2907. PMC317701. PMID 2726448.CS1 maint: uses authors parameter (link)
Yamano S, Nagata K, Yamazoe Y และคณะ (1989). "cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)". Nucleic Acids Res. 17 (12): 4888. doi:10.1093/nar/17.12.4888. PMC318052. PMID 2748347.CS1 maint: uses authors parameter (link)
Phillips IR, Shephard EA, Ashworth A, Rabin BR (1985). "Isolation and sequence of a human cytochrome P-450 cDNA clone". Proc. Natl. Acad. Sci. U.S.A. 82 (4): 983–7. doi:10.1073/pnas.82.4.983. PMC397177. PMID 3856261.CS1 maint: uses authors parameter (link)
Wainwright BJ, Watson EK, Shephard EA, Phillips IR (1985). "RFLP for a human cytochrome P-450 gene at 19q13.1-qter (HGM8 provisional designation CYPI)". Nucleic Acids Res. 13 (12): 4610. doi:10.1093/nar/13.12.4610. PMC321810. PMID 4011450.CS1 maint: uses authors parameter (link)
Fernandez-Salguero P, Hoffman SM, Cholerton S และคณะ (1995). "A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles". Am. J. Hum. Genet. 57 (3): 651–60. PMC1801261. PMID 7668294.CS1 maint: uses authors parameter (link)
Ding S, Lake BG, Friedberg T, Wolf CR (1995). "Expression and alternative splicing of the cytochrome P-450 CYP2A7". Biochem. J. 306. ( Pt 1): 161–6. PMC1136496. PMID 7864805.CS1 maint: uses authors parameter (link)
Hoffman SM, Fernandez-Salguero P, Gonzalez FJ, Mohrenweiser HW (1996). "Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19". J. Mol. Evol. 41 (6): 894–900. doi:10.1007/bf00173169. PMID 8587134.CS1 maint: uses authors parameter (link)
Hadidi H, Zahlsen K, Idle JR, Cholerton S (1998). "A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin". Food Chem. Toxicol. 35 (9): 903–7. doi:10.1016/S0278-6915(97)00066-5. PMID 9409631.CS1 maint: uses authors parameter (link)
Oscarson M, Gullstén H, Rautio A และคณะ (1998). "Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase". FEBS Lett. 438 (3): 201–5. doi:10.1016/S0014-5793(98)01297-6. PMID 9827545.CS1 maint: uses authors parameter (link)
cyp2a6, ไซโทโครม, p450, งกฤษ, cytochrome, p450, อย, เป, นโปรต, นในมหาสก, ลไซโทโครม, p450, งเป, นระบบเอนไซม, ออกซ, เดซอเนกประสงค, ของร, างกายมน, ษย, โดยการแสดงออกของ, นจะถ, กควบค, มโดยย, บน, โครโมโซมค, โลค, 19q13, และถ, อเป, นย, นอ, กชน, ดหน, งในกล, มย, cytochr. isothokhrm P450 2A6 xngkvs Cytochrome P450 2A6 chuxyx CYP2A6 EC 1 14 14 1 epnoprtininmhaskulisothokhrm P450 sungepnrabbexnismxxksiedsxenkprasngkhkhxngrangkaymnusy 3 odykaraesdngxxkkhxng CYP2A6 nncathukkhwbkhumodyyin CYP2A6 bn okhromosmkhuthi 19 olkhs 19q13 2 aelathuxepnyinxikchnidhnunginklumyin cytochrome P450 3 4 ody CYP2A6 khxngmnusycamihnathiinkratunkarekidemaethbxlisumkhxngsarsioniboxtikhinrangkay nxkcakni CYP2A6 yngthuxepnexnismhlkthicamikaraesdngxxkephuxihekidptikiriyaxxksiedchnkhxngniokhtinaelaokhtinin emuxmisarthngsxngekhamainrabb nxkehnuxcaknncaepnkaremaethbxilsyachnidtang sarkxmaerng xlkhalxydcaphwkkhumarin ody CYP2A6 epnexnismephiyngchnidediywinrangkaymnusythimikhwamsamarthinkarkratunkarekidptikiriya 7 hydroxylation ephuxemaethbxilskhumarin odysarthiekidcakptikiriyakaremaethbxilsnikhux 7 hydroxycoumarin sungichepntwchiwdkarthangankhxng CYP2A6 3 CYP2A6Available structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes4RUI 1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS 3T3Q 3T3R 4EJJIdentifiersAliasesCYP2A6 CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB cytochrome P450 family 2 subfamily A member 6External IDsOMIM 122720 HomoloGene 85917 GeneCards CYP2A6Gene location Human Chr Chromosome 19 human 1 Band19q13 2Start40 843 541 bp 1 End40 850 447 bp 1 Gene ontologyMolecular function iron ion binding arachidonic acid epoxygenase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen metal ion binding monooxygenase activity heme binding oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen enzyme binding oxidoreductase activity coumarin 7 hydroxylase activity steroid hydroxylase activityCellular component organelle membrane endoplasmic reticulum membrane eyuxhum intracellular membrane bounded organelle rangaehexnodphlasum cytoplasmic microtubule isothphlasumBiological process steroid metabolic process exogenous drug catabolic process epoxygenase P450 pathway coumarin catabolic process drug metabolic process coumarin metabolic process organic acid metabolic process xenobiotic metabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1548n aEnsemblENSG00000255974n aUniProtP11509n aRefSeq mRNA NM 000762n aRefSeq protein NP 000753n aLocation UCSC Chr 19 40 84 40 85 Mbn aPubMed search 2 n aWikidataView Edit Humanokhrngsrangphlukkhxngimokhrosmxl P450 2A6 khxngmnusythicbxyukbsarybyngchnid 5 Pyridin 3 yl furan 2 yl methanamine rhsthaebiynoprtin 2fdw thngni CYP2A6 edimchux CYP2A3 thuxepnsmachikkhxngklumexnismkhnadihykhxngisothokhrm P450 thimiyinkhwbkhumxyubnokhromosm 19q echnediywknexnismxuninskulyxy CYP2A CYP2B aela CYP2F aetinphayhlngmikarphicarnaepliynchuxexnismnicak CYP2A3 epn CYP2A6 3 enuxngcakchuxedimsasxnkb CYP2A3 thiphbinhnu aetmiokhrngsrangaelahnathiaetktangkn 5 6 enuxha 1 karkracayaelakhwamphnaepr 2 twxyangphngptismphnth 3 liaekndkhxng CYP2A6 4 duephim 5 xangxing 6 aehlngkhxmulxunkarkracayaelakhwamphnaepr aekikhkarkracaykhxng CYP2A6 inenuxeyuxkhxngrangkaynncaphbxyuinrangaehexnodphlasumepnhlk aelamiprimanmakthisudinesllenuxeyuxtb 4 7 swnkaraesdngxxkkhxng CYP2A6 nncaphbidmakineslltb thungnadi aelaeslleyuxbuophrngcmuk Nasal Respiratory Epithellium 7 swnkhwamphnaeprradbyinkhxng CYP2A6 nnwamikhwamphnaeprrahwangbukhkhlkhxng CYP2A6 xaophoprtin aelaradbexmxarexnexkhxngyinnixyangminysakhy 8 twxyangphngptismphnth aekikhCYP2A6 epnexnismthiekiywkhxngkbkrabwntangkhxngrangkaymakmay odyechphaadankaraephthy twxyangechn thikaefxr sungepnyainrupoprdrk thiichinkarrksamaernghlaychnid caepntxngthukepliynihepn fluxxoryurasil sungrupthixxkvththi active form dwy CYP2A6 ineslltb 9 10 11 dngphngptismphnthdanlangkhlikeluxkthichuxyin oprtin hruxsaremaethbxiltdanlang ephuxechuxmoyngipyngbthkhwamwikiphiediythiekiywenuxng 1 File bSize px alt Fluorouracil 5 FU Activity edit Fluorouracil 5 FU Activity edit The interactive pathway map can be edited at WikiPathways FluoropyrimidineActivity WP1601 liaekndkhxng CYP2A6 aekikhliaekndkhxng CYP2A6 nnmihlaychnid odyaebngxxkidepn 3 klum khux liaekndthiepnsarsbsetrt sarehniywna Inducer aelasarybyng inhibitor dngaesdngintarangdanlang odyliaekndhlkthisamarthehniywnaephuxephimkarthangankhxng CYP2A6 thiphbidbxymakthisud khux fionbarbithxl iraefmphisin aelayaknchkbangchnid 12 sarsbsetrt sarybyng sarehniywnasarkxmaerng MNAN NNK NDEA MTBE thxksinxun xaflathxksin bi1 imokhthxksin 1 3 butadiene inyangsngekhraah khumarin tankaraekhngtwkhxngeluxd phbinxbechy DCBN sarkacdwchphuch 7 ethoxycoumarin sbsetrtthdsxbexnism skaotl khwionlin MOCA inkarphlitophliyuriethn haolethn yacha olsikaomn yaknchk emthxksifluaern yacha okhtinin emaethbxiltkhxngniokhtin niokhtin sarkratun SM 12502 tanPAF krdwaophrxik yaknchk yakhwbkhumxarmn edksemedothmidin yarangbprasath 12 xamioxdaorn yatanphawahwicetnphidcnghwa 12 aexmoldipin aekhlesiymaechnaenlblxkekxr 12 biwphrinxrfin oxpixxydkungsngekhraah 12 khlxifebrt ifebrt 12 khlxitrmaosl yatanechuxra 12 edsiphramin yaaeksumesraklumitriskhlik 12 idslfiaerm ybyngxldiihd diihodrciens 12 exntakhaopn ybyng COMT ichinorkhpharkhinsn 12 fionifebrt ifebrt 12 kabaephntin yaknchk flaownxydinnaekrpfrut ixosinxasid yaptichiwna 12 13 khiotokhnaosl yatanechuxra 12 elothrosl ybyngxaormaeths ichinmaerngetanm 12 emthimaosl rksaorkhithrxyd 12 emthxksaeln furaonkhumarin ichinorkhsaekdengin 12 emithraophn ichinkarwinicchyphawatxmhmwkitthanganimephiyngphx 12 imokhnaosl yatanechuxra 12 omdafinil thaihtuntw 12 niokhtin sarkratun 12 xxefendrin sartanhistamin 12 ipholkharphin kratuntwrbmskharinik 12 phrikabalin yaknchk eselkilin ybyngmxnxexminxxksieds 12 14 slokhnaosl yatanechuxra 12 ithoxokhnaosl yatanechuxra 12 thranilsyoprmin ybyngmxnxexminxxksieds 12 barbiechxrit xombarbithxll 12 ephnothbarbithxl 12 fionbarbithxl 12 esokhbarbithxl 12 iraefmphisin yaptichiwna 12 duephim aekikhkhxmmxns miphaphaelasuxekiywkb CYP2A6 ephschkrrmisotokhrm P450 emaethbxlisumkhxngya raychuxsarklasyyankhxngisothokhrm P450xangxing aekikh 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000255974 Ensembl May 2017 Human PubMed Reference 3 0 3 1 3 2 3 3 Entrez Gene CYP2A6 cytochrome P450 family 2 subfamily A polypeptide 6 4 0 4 1 National Center for Biotechnology Information April 8 2018 CYP2A6 cytochrome P450 family 2 subfamily A member 6 Homo sapiens human U S National Library of Medicine ekb cakaehlngedimemux 2016 10 01 subkhnemux April 12 2018 Hellmold H Magnusson M Pelto Huikko M Rylander T Gustafsson J Warner M 1998 Identification of CYP2A3 as a major cytochrome P450 enzyme in the female peripubertal rat breast PDF Mol Pharmacol 53 3 475 82 PMID 9495814 Unknown parameter month ignored help CS1 maint multiple names authors list link National Center for Biotechnology Information March 13 2018 Cyp2a3 cytochrome P450 family 2 subfamily a polypeptide 3 Rattus norvegicus Norway rat U S National Library of Medicine khlngkhxmuleka ekbcak aehlngedim emux April 12 2018 subkhnemux April 12 2018 7 0 7 1 Weizmann Institute of Science 2018 CYP2A6 Gene Protein Coding khlngkhxmuleka ekbcak aehlngedim emux January 3 2018 subkhnemux April 12 2018 A B RENWICK P S Watts R J Edwards P T Barton I Guyonnet R J Price J M Tredger O Pelkonen A R Boobis and B G Lake 2000 Differential Maintenance of Cytochrome P450 Enzymes in Cultured Precision cut Human Liver Slices PDF The American Society for Pharmacology and Experimental Therapeutics 28 10 1202 9 PMID 10997941 Unknown parameter month ignored help CS1 maint multiple names authors list link El Sayed YM Sadee W 1983 Metabolic activation of R S 1 tetrahydro 2 furanyl 5 fluorouracil ftorafur to 5 fluorouracil by soluble enzymes Cancer Research 43 9 4039 44 PMID 6409396 Nakayama T Noguchi S January 2010 Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur Uracil UFT in patients with breast cancer focus on the results of clinical studies in Japan PDF The Oncologist 15 1 26 36 doi 10 1634 theoncologist 2009 0255 PMC 3227888 PMID 20080863 Matt P van Zwieten Boot B Calvo Rojas G Ter Hofstede H Garcia Carbonero R Camarero J Abadie E Pignatti F October 2011 The European Medicines Agency review of Tegafur Gimeracil Oteracil Teysuno for the treatment of advanced gastric cancer when given in combination with cisplatin summary of the Scientific Assessment of the Committee for medicinal products for human use CHMP PDF The Oncologist 16 10 1451 1457 doi 10 1634 theoncologist 2011 0224 PMC 3228070 PMID 21963999 CS1 maint uses authors parameter link 12 00 12 01 12 02 12 03 12 04 12 05 12 06 12 07 12 08 12 09 12 10 12 11 12 12 12 13 12 14 12 15 12 16 12 17 12 18 12 19 12 20 12 21 12 22 12 23 12 24 12 25 12 26 12 27 12 28 12 29 12 30 Lacy CF Armstrong LL Goldman MP Lance LL 2007 Cytochrome P450 Enzymes Substrates Inhibitors and Inducers Hudson OH LexiComp Inc pp 1899 1912 CS1 maint uses authors parameter link Wen X Wang JS Neuvonen PJ Backman JT 2002 Isoniazid is a mechanism based inhibitor of cytochrome P450 1A2 2A6 2C19 and 3A4 isoforms in human liver microsomes Eur J Clin Pharmacol 57 11 799 804 doi 10 1007 s00228 001 0396 3 PMID 11868802 CS1 maint uses authors parameter link Siu EC Tyndale RF 2008 Selegiline is a mechanism based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice J Pharmacol Exp Ther 324 3 992 9 doi 10 1124 jpet 107 133900 PMID 18065502 CS1 maint uses authors parameter link aehlngkhxmulxun aekikhPelkonen O Rautio A Raunio H Pasanen M 2000 CYP2A6 a human coumarin 7 hydroxylase Toxicology 144 1 3 139 47 doi 10 1016 S0300 483X 99 00200 0 PMID 10781881 CS1 maint uses authors parameter link Fernandez Salguero P Gonzalez FJ 1995 The CYP2A gene subfamily species differences regulation catalytic activities and role in chemical carcinogenesis Pharmacogenetics 5 Special Issue S123 8 doi 10 1097 00008571 199512001 00013 PMID 7581481 CS1 maint uses authors parameter link Smith G Stubbins MJ Harries LW Wolf CR 1999 Molecular genetics of the human cytochrome P450 monooxygenase superfamily Xenobiotica 28 12 1129 65 doi 10 1080 004982598238868 PMID 9890157 CS1 maint uses authors parameter link Pelkonen O Rautio A Raunio H Pasanen M 2000 CYP2A6 a human coumarin 7 hydroxylase Toxicology 144 1 3 139 47 doi 10 1016 S0300 483X 99 00200 0 PMID 10781881 CS1 maint uses authors parameter link Tyndale RF Sellers EM 2002 Genetic variation in CYP2A6 mediated nicotine metabolism alters smoking behavior Therapeutic drug monitoring 24 1 163 71 doi 10 1097 00007691 200202000 00026 PMID 11805739 CS1 maint uses authors parameter link Xu C Goodz S Sellers EM Tyndale RF 2003 CYP2A6 genetic variation and potential consequences Adv Drug Deliv Rev 54 10 1245 56 doi 10 1016 S0169 409X 02 00065 0 PMID 12406643 CS1 maint uses authors parameter link Kamataki T Fujieda M Kiyotani K aelakhna 2005 Genetic polymorphism of CYP2A6 as one of the potential determinants of tobacco related cancer risk Biochem Biophys Res Commun 338 1 306 10 doi 10 1016 j bbrc 2005 08 268 PMID 16176798 CS1 maint uses authors parameter link Maurice M Emiliani S Dalet Beluche I aelakhna 1991 Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes Eur J Biochem 200 2 511 7 doi 10 1111 j 1432 1033 1991 tb16212 x PMID 1889415 CS1 maint uses authors parameter link Yun CH Shimada T Guengerich FP 1991 Purification and characterization of human liver microsomal cytochrome P 450 2A6 Mol Pharmacol 40 5 679 85 PMID 1944238 CS1 maint uses authors parameter link Yamano S Tatsuno J Gonzalez FJ 1990 The CYP2A3 gene product catalyzes coumarin 7 hydroxylation in human liver microsomes Biochemistry 29 5 1322 9 doi 10 1021 bi00457a031 PMID 2322567 CS1 maint uses authors parameter link Miles JS Bickmore W Brook JD aelakhna 1989 Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies implications for the assignment of substrate specificity Nucleic Acids Res 17 8 2907 17 doi 10 1093 nar 17 8 2907 PMC 317701 PMID 2726448 CS1 maint uses authors parameter link Yamano S Nagata K Yamazoe Y aelakhna 1989 cDNA and deduced amino acid sequences of human P450 IIA3 CYP2A3 Nucleic Acids Res 17 12 4888 doi 10 1093 nar 17 12 4888 PMC 318052 PMID 2748347 CS1 maint uses authors parameter link Phillips IR Shephard EA Ashworth A Rabin BR 1985 Isolation and sequence of a human cytochrome P 450 cDNA clone Proc Natl Acad Sci U S A 82 4 983 7 doi 10 1073 pnas 82 4 983 PMC 397177 PMID 3856261 CS1 maint uses authors parameter link Wainwright BJ Watson EK Shephard EA Phillips IR 1985 RFLP for a human cytochrome P 450 gene at 19q13 1 qter HGM8 provisional designation CYPI Nucleic Acids Res 13 12 4610 doi 10 1093 nar 13 12 4610 PMC 321810 PMID 4011450 CS1 maint uses authors parameter link Fernandez Salguero P Hoffman SM Cholerton S aelakhna 1995 A genetic polymorphism in coumarin 7 hydroxylation sequence of the human CYP2A genes and identification of variant CYP2A6 alleles Am J Hum Genet 57 3 651 60 PMC 1801261 PMID 7668294 CS1 maint uses authors parameter link Ding S Lake BG Friedberg T Wolf CR 1995 Expression and alternative splicing of the cytochrome P 450 CYP2A7 Biochem J 306 Pt 1 161 6 PMC 1136496 PMID 7864805 CS1 maint uses authors parameter link Hoffman SM Fernandez Salguero P Gonzalez FJ Mohrenweiser HW 1996 Organization and evolution of the cytochrome P450 CYP2A 2B 2F subfamily gene cluster on human chromosome 19 J Mol Evol 41 6 894 900 doi 10 1007 bf00173169 PMID 8587134 CS1 maint uses authors parameter link Hadidi H Zahlsen K Idle JR Cholerton S 1998 A single amino acid substitution Leu160His in cytochrome P450 CYP2A6 causes switching from 7 hydroxylation to 3 hydroxylation of coumarin Food Chem Toxicol 35 9 903 7 doi 10 1016 S0278 6915 97 00066 5 PMID 9409631 CS1 maint uses authors parameter link Oscarson M Gullsten H Rautio A aelakhna 1998 Genotyping of human cytochrome P450 2A6 CYP2A6 a nicotine C oxidase FEBS Lett 438 3 201 5 doi 10 1016 S0014 5793 98 01297 6 PMID 9827545 CS1 maint uses authors parameter link bthkhwamnirwbrwmkhxmulcakhxsmudaephthysastraehngchatixemrikn sungcdepnsatharnsmbti ekhathungcak https th wikipedia org w index php title CYP2A6 amp oldid 9557366, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
