• monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • aromatase activity • heme binding • metal ion binding • iron ion binding • oxidoreductase activity • oxygen binding • arachidonic acid epoxygenase activity • steroid hydroxylase activity
• epoxygenase P450 pathway • organic acid metabolic process • xenobiotic metabolic process • coumarin metabolic process • exogenous drug catabolic process
↑ GRCh38: Ensembl release 89: ENSG00000198077 - Ensembl, May 2017
"Human PubMed Reference:".
Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR (September 1995). "A Genetic Polymorphism in Coumarin 7-Hydroxylation: Sequence of the Human CYP2A Gnes and Identification of Variant CYP2A6 Alleles". Am. J. Hum. Genet. 57 (3): 651–60. PMC1801261. PMID 7668294.CS1 maint: uses authors parameter (link)
Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (January 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.CS1 maint: uses authors parameter (link)
Smith BD, Sanders JL, Porubsky PR และคณะ (2007). "Structure of the human lung cytochrome P450 2A13". J. Biol. Chem. 282 (23): 17306–13. doi:10.1074/jbc.M702361200. PMID 17428784.CS1 maint: uses authors parameter (link)
Wang HH, Liao YW, Chiang HL และคณะ (2009). "Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population". Pharmacogenomics. 10 (3): 359–74. doi:10.2217/14622416.10.3.359. PMID 19290787.CS1 maint: uses authors parameter (link)
Fernandez-Salguero P, Gonzalez FJ (1995). "The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis". Pharmacogenetics. 5 (Special Issue): S123–8. doi:10.1097/00008571-199512001-00013. PMID 7581481.CS1 maint: uses authors parameter (link)
Cauffiez C, Lo-Guidice JM, Quaranta S และคณะ (2004). "Genetic polymorphism of the human cytochrome CYP2A13 in a French population: implication in lung cancer susceptibility". Biochem. Biophys. Res. Commun. 317 (2): 662–9. doi:10.1016/j.bbrc.2004.03.092. PMID 15063809.CS1 maint: uses authors parameter (link)
Smith G, Stubbins MJ, Harries LW, Wolf CR (1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica. 28 (12): 1129–65. doi:10.1080/004982598238868. PMID 9890157.CS1 maint: uses authors parameter (link)
Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". J. Hum. Genet. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046.CS1 maint: uses authors parameter (link)
He XY, Shen J, Ding X และคณะ (2004). "Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen". Drug Metab. Dispos. 32 (12): 1516–21. doi:10.1124/dmd.104.001370. PMID 15333516.CS1 maint: uses authors parameter (link)
Nelson DR, Zeldin DC, Hoffman SM และคณะ (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.CS1 maint: uses authors parameter (link)
He XY, Shen J, Hu WY และคณะ (2004). "Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation". Arch. Biochem. Biophys. 427 (2): 143–53. doi:10.1016/j.abb.2004.03.016. PMID 15196988.CS1 maint: uses authors parameter (link)
Herr D, Bettendorf H, Denschlag D และคณะ (2006). "Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma". Arch. Gynecol. Obstet. 274 (6): 367–71. doi:10.1007/s00404-006-0201-8. PMID 16835796.CS1 maint: uses authors parameter (link)
Song DK, Xing DL, Zhang LR และคณะ (2009). "Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China". Cancer Detect. Prev. 32 (5–6): 416–23. doi:10.1016/j.cdp.2009.02.003. PMID 19303722.CS1 maint: uses authors parameter (link)
Fujieda M, Yamazaki H, Kiyotani K และคณะ (2003). "Eighteen novel polymorphisms of the CYP2A13 gene in Japanese". Drug Metab. Pharmacokinet. 18 (1): 86–90. doi:10.2133/dmpk.18.86. PMID 15618722.CS1 maint: uses authors parameter (link)
Wang H, Tan W, Hao B และคณะ (2003). "Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK". Cancer Res. 63 (22): 8057–61. PMID 14633739.CS1 maint: uses authors parameter (link)
Cheng XY, Chen GL, Zhang WX และคณะ (2004). "Arg257Cys polymorphism of CYP2A13 in a Chinese population". Clin. Chim. Acta. 343 (1–2): 213–6. doi:10.1016/j.cccn.2004.01.017. PMID 15115698.CS1 maint: uses authors parameter (link)
D'Agostino J, Zhang X, Wu H และคณะ (2008). "Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers". Drug Metab. Dispos. 36 (11): 2316–23. doi:10.1124/dmd.108.022822. PMC2597635. PMID 18669584.CS1 maint: uses authors parameter (link)
Cauffiez C, Pottier N, Tournel G และคณะ (2005). "CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations". Xenobiotica. 35 (7): 661–9. doi:10.1080/00498250500202171. PMID 16316926.CS1 maint: uses authors parameter (link)
Mohelnikova-Duchonova B, Vrana D, Holcatova I และคณะ (2010). "CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk". Pancreas. 39 (2): 144–8. doi:10.1097/MPA.0b013e3181bab6c2. PMID 19812523.CS1 maint: uses authors parameter (link)
Jiang JH, Jia WH, Chen HK และคณะ (2004). "Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population". J Transl Med. 2 (1): 24. doi:10.1186/1479-5876-2-24. PMC455696. PMID 15222883.CS1 maint: uses authors parameter (link)
Young RP, Hopkins RJ, Hay BA และคณะ (2009). "A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers". Postgrad Med J. 85 (1008): 515–24. doi:10.1136/pgmj.2008.077107. PMID 19789190.CS1 maint: uses authors parameter (link)
cyp2a7, ไซโทโครม, p450, งกฤษ, cytochrome, p450, อย, เป, นสมาช, กพอล, เปปไทด, ลำด, บท, ในสก, ลย, อย, ของสก, ลท, ในมหาสก, ลไซโทโครม, p450, ดเป, นโปรต, นอ, กชน, ดหน, งท, ณสมบ, เป, นเอนไซม, โดยม, เป, นต, วควบค, มการแสดงออก, งย, นน, เป, นส, วนหน, งของกล, มย, cytoch. isothokhrm P450 2A7 xngkvs Cytochrome P450 2A7 chuxyx CYP2A7 EC 1 14 14 1 epnsmachikphxlieppithdladbthi 7 inskulyxy A khxngskulthi 2 inmhaskulisothokhrm P450 cdepnoprtinxikchnidhnungthimikhunsmbtiepnexnismodymiyin CYP2A7 epntwkhwbkhumkaraesdngxxk 3 4 sungyinniepnswnhnungkhxngklumyin cytochrome P450 bn okhromosmkhuthi 19 olkhs 19q13 2 5 CYP2A7IdentifiersAliasesCYP2A7 CPA7 CPAD CYP2A CYPIIA7 P450 IIA4 cytochrome P450 family 2 subfamily A member 7External IDsOMIM 608054 HomoloGene 85917 GeneCards CYP2A7Gene location Human Chr Chromosome 19 human 1 Band19q13 2Start40 875 439 bp 1 End40 882 752 bp 1 Gene ontologyMolecular function monooxygenase activity oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen reduced flavin or flavoprotein as one donor and incorporation of one atom of oxygen aromatase activity heme binding metal ion binding iron ion binding oxidoreductase activity oxygen binding arachidonic acid epoxygenase activity steroid hydroxylase activityCellular component eyuxhum intracellular membrane bounded organelle endoplasmic reticulum membrane organelle membrane rangaehexnodphlasum isothphlasumBiological process epoxygenase P450 pathway organic acid metabolic process xenobiotic metabolic process coumarin metabolic process exogenous drug catabolic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1549n aEnsemblENSG00000198077n aUniProtP20853n aRefSeq mRNA NM 000764NM 030589n aRefSeq protein NP 000755NP 085079n aLocation UCSC Chr 19 40 88 40 88 Mbn aPubMed search 2 n aWikidataView Edit Humanexnisminmhaskulisothokhrm P450 sungrwmthung CYP2A7 nncdepnexnismchnidmxnxxxksiciens sungmihnathisakhyinkarerngptikiryakarekidemaethbxlisumkhxngyachnidtang rwmipthungkarsngekhraahkhxelsetxrxl setxrxyd aelakrdikhmnchnidxun odyexnismehlanicaekhluxnthiekhasurangaehexnodphlasum aelwthukkratundwykluokhkhxrtikhxydcungcasamarthaesdngkhunsmbtikhxngexnismnnid xyangirktam sarthiepnsbsetrtkhxng CYP2A7 nnyngimmikarcaaenkaelarabuidaenchd oprtin CYP2A7 thiphbinmnusypccubnmithngsin 2 ixosfxrm thngni CYP2A7 thuxepnsmachikkhxngklumexnismkhnadihykhxngisothokhrm P450thimiyinkhwbkhumxyubnokhromosm 19q echnediywknexnismxuninskulyxy CYP2A CYP2B aela CYP2F 5 duephim aekikhkhxmmxns miphaphaelasuxekiywkb CYP2A7 ephschkrrmisotokhrm P450 emaethbxlisumkhxngyaxangxing aekikh 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000198077 Ensembl May 2017 Human PubMed Reference Fernandez Salguero P Hoffman SM Cholerton S Mohrenweiser H Raunio H Rautio A Pelkonen O Huang JD Evans WE Idle JR September 1995 A Genetic Polymorphism in Coumarin 7 Hydroxylation Sequence of the Human CYP2A Gnes and Identification of Variant CYP2A6 Alleles Am J Hum Genet 57 3 651 60 PMC 1801261 PMID 7668294 CS1 maint uses authors parameter link Nelson DR Zeldin DC Hoffman SM Maltais LJ Wain HM Nebert DW January 2004 Comparison of cytochrome P450 CYP genes from the mouse and human genomes including nomenclature recommendations for genes pseudogenes and alternative splice variants Pharmacogenetics 14 1 1 18 doi 10 1097 00008571 200401000 00001 PMID 15128046 CS1 maint uses authors parameter link 5 0 5 1 Entrez Gene CYP2A7 aehlngkhxmulxun aekikhtaaehnngcionm CYP2A7 khxngmnusy aelahnaephcaesdngkhxmulekiywkbyin CYP2A7 in UCSC Genome Browser Smith BD Sanders JL Porubsky PR aelakhna 2007 Structure of the human lung cytochrome P450 2A13 J Biol Chem 282 23 17306 13 doi 10 1074 jbc M702361200 PMID 17428784 CS1 maint uses authors parameter link Wang HH Liao YW Chiang HL aelakhna 2009 Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population Pharmacogenomics 10 3 359 74 doi 10 2217 14622416 10 3 359 PMID 19290787 CS1 maint uses authors parameter link Fernandez Salguero P Gonzalez FJ 1995 The CYP2A gene subfamily species differences regulation catalytic activities and role in chemical carcinogenesis Pharmacogenetics 5 Special Issue S123 8 doi 10 1097 00008571 199512001 00013 PMID 7581481 CS1 maint uses authors parameter link Cauffiez C Lo Guidice JM Quaranta S aelakhna 2004 Genetic polymorphism of the human cytochrome CYP2A13 in a French population implication in lung cancer susceptibility Biochem Biophys Res Commun 317 2 662 9 doi 10 1016 j bbrc 2004 03 092 PMID 15063809 CS1 maint uses authors parameter link Timofeeva MN Kropp S Sauter W aelakhna 2009 CYP450 polymorphisms as risk factors for early onset lung cancer gender specific differences Carcinogenesis 30 7 1161 9 doi 10 1093 carcin bgp102 PMID 19414505 CS1 maint uses authors parameter link Smith G Stubbins MJ Harries LW Wolf CR 1998 Molecular genetics of the human cytochrome P450 monooxygenase superfamily Xenobiotica 28 12 1129 65 doi 10 1080 004982598238868 PMID 9890157 CS1 maint uses authors parameter link Saito A Kawamoto M Kamatani N 2009 Association study between single nucleotide polymorphisms in 199 drug related genes and commonly measured quantitative traits of 752 healthy Japanese subjects J Hum Genet 54 6 317 23 doi 10 1038 jhg 2009 31 PMID 19343046 CS1 maint uses authors parameter link He XY Shen J Ding X aelakhna 2004 Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4 methylnitrosamino 1 3 pyridyl 1 butanone a tobacco specific carcinogen Drug Metab Dispos 32 12 1516 21 doi 10 1124 dmd 104 001370 PMID 15333516 CS1 maint uses authors parameter link Nelson DR Zeldin DC Hoffman SM aelakhna 2004 Comparison of cytochrome P450 CYP genes from the mouse and human genomes including nomenclature recommendations for genes pseudogenes and alternative splice variants Pharmacogenetics 14 1 1 18 doi 10 1097 00008571 200401000 00001 PMID 15128046 CS1 maint uses authors parameter link He XY Shen J Hu WY aelakhna 2004 Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7 hydroxylation Arch Biochem Biophys 427 2 143 53 doi 10 1016 j abb 2004 03 016 PMID 15196988 CS1 maint uses authors parameter link Herr D Bettendorf H Denschlag D aelakhna 2006 Cytochrome P2A13 and P1A1 gene polymorphisms are associated with the occurrence of uterine leiomyoma Arch Gynecol Obstet 274 6 367 71 doi 10 1007 s00404 006 0201 8 PMID 16835796 CS1 maint uses authors parameter link Song DK Xing DL Zhang LR aelakhna 2009 Association of NAT2 GSTM1 GSTT1 CYP2A6 and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China Cancer Detect Prev 32 5 6 416 23 doi 10 1016 j cdp 2009 02 003 PMID 19303722 CS1 maint uses authors parameter link Fujieda M Yamazaki H Kiyotani K aelakhna 2003 Eighteen novel polymorphisms of the CYP2A13 gene in Japanese Drug Metab Pharmacokinet 18 1 86 90 doi 10 2133 dmpk 18 86 PMID 15618722 CS1 maint uses authors parameter link Wang H Tan W Hao B aelakhna 2003 Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13 the most active cytochrome P450 for the metabolic activation of tobacco specific carcinogen NNK Cancer Res 63 22 8057 61 PMID 14633739 CS1 maint uses authors parameter link Cheng XY Chen GL Zhang WX aelakhna 2004 Arg257Cys polymorphism of CYP2A13 in a Chinese population Clin Chim Acta 343 1 2 213 6 doi 10 1016 j cccn 2004 01 017 PMID 15115698 CS1 maint uses authors parameter link D Agostino J Zhang X Wu H aelakhna 2008 Characterization of CYP2A13 2 a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers Drug Metab Dispos 36 11 2316 23 doi 10 1124 dmd 108 022822 PMC 2597635 PMID 18669584 CS1 maint uses authors parameter link Cauffiez C Pottier N Tournel G aelakhna 2005 CYP2A13 genetic polymorphism in French Caucasian Gabonese and Tunisian populations Xenobiotica 35 7 661 9 doi 10 1080 00498250500202171 PMID 16316926 CS1 maint uses authors parameter link Mohelnikova Duchonova B Vrana D Holcatova I aelakhna 2010 CYP2A13 ADH1B and ADH1C gene polymorphisms and pancreatic cancer risk Pancreas 39 2 144 8 doi 10 1097 MPA 0b013e3181bab6c2 PMID 19812523 CS1 maint uses authors parameter link Jiang JH Jia WH Chen HK aelakhna 2004 Genetic polymorphisms of CYP2A13 and its relationship to nasopharyngeal carcinoma in the Cantonese population J Transl Med 2 1 24 doi 10 1186 1479 5876 2 24 PMC 455696 PMID 15222883 CS1 maint uses authors parameter link Young RP Hopkins RJ Hay BA aelakhna 2009 A gene based risk score for lung cancer susceptibility in smokers and ex smokers Postgrad Med J 85 1008 515 24 doi 10 1136 pgmj 2008 077107 PMID 19789190 CS1 maint uses authors parameter link bthkhwamnirwbrwmkhxmulcakhxsmudaephthysastraehngchatixemrikn sungcdepnsatharnsmbtiekhathungcak https th wikipedia org w index php title CYP2A7 amp oldid 7558225, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
