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วิกิพีเดีย

ฮีทช็อคโปรตีน 47

สิงหาคม 08, 2021

ฮีทช็อคโปรตีน 47 หรือ เซอร์ปิน เอช1 (อังกฤษ: Heat shock protein 47; HSP47 หรือ SERPINH1) เป็นโปรตีนกลุ่มเซอร์ปินชนิดหนึ่งที่พบในมุษย์ มีบทบาทสำคัญในกระบวนการการสร้างคอลลาเจน ถูกถอดรหัสได้จากยีน SERPINH1 บนโครโมโซมคู่ที่ 11

SERPINH1
Identifiers
AliasesSERPINH1, AsTP3, CBP1, CBP2, HSP47, OI10, PIG14, PPROM, RA-A47, SERPINH2, gp46, serpin family H member 1
External IDsOMIM: 600943 HomoloGene: 20331 GeneCards: SERPINH1
Gene location (Human)
Chr.Chromosome 11 (human)
Band11q13.5Start75,562,056 bp
End75,572,783 bp
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

871

n/a

Ensembl

ENSG00000149257

n/a

UniProt

P50454

n/a

RefSeq (mRNA)

NM_001207014
NM_001235

n/a

RefSeq (protein)

NP_001193943
NP_001226

n/a

Location (UCSC)Chr 11: 75.56 – 75.57 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

หน้าที่

HSP47 เป็นสมาชิกหนึ่งในโปรตีนมหาวงศ์เซอร์ปิน ทำหน้าที่ยับยั้งการทำงานของเอนไซม์ซีรีนโปรตีเอส การแสดงออกของโปรตีนชนิดนี้สามารถเหนี่ยวนำได้โดยการกระตุ้นเซลล์ให้เกิดความเครียดด้วยความร้อน (heat shock) โดยจะพบการแสดงออกของ HSP47 ในเซลล์ที่มีร่างแหเอนโดพลาซึม ซึ่งเซลล์เหล่านี้จะสร้างและหลั่งคอลลาเจนชนิด I และชนิด II HSP47 จะเคลื่อนที่เข้าไปยัง lumen ของร่างแหเอนโดพลาซึมและเข้าจับกับคอลลาเจน ดังนั้นจึงคาดการณ์ได้ว่า HSP47 เป็นแชพเพอรอนที่ทำหน้าที่เกี่ยวข้องกับการดัดแปลงโมเลกุลของคอลลาเจนให้มีสภาพพร้อมทำงาน อย่างไรก็ตาม ในผู้ป่วยโรคข้ออักเสบรูมาตอยด์อาจพบการแสดงออกของ HSP47 ได้น้อยกว่าปกติ เนื่องจากมีการสร้างสารภูมิต้านทานต้านตนเอง (autoantibody) ต่อ HSP47

อันตรกิริยา

HSP47 สามารถเกิดอันตรกิริยากับคอลลาเจนชนิด I, II, III, IV และ V ได้


ลำดับกรดอะมิโน
1020304050
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGL
AFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAE
QLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSS
KQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALL
VNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEK
EKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKK
AVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLAS
VFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSL
LFIGRLVRPKGDKMRDEL

อ้างอิง

  1. ↑ GRCh38: Ensembl release 89: ENSG00000149257 - Ensembl, May 2017
  2. "Human PubMed Reference:".
  3. ↑ "Entrez Gene: SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)".
  4. Dafforn TR, Della M, Miller AD (December 2001). "The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis". The Journal of Biological Chemistry. 276 (52): 49310–9. doi:10.1074/jbc.M108896200. PMID 11592970.
  5. Williams, R. Sanders (21 March 2000). "Heat Shock Protein 47: A Chaperone for the Fibrous Cap?". Circulation (ภาษาอังกฤษ). 101 (11): 1227–1228. doi:10.1161/01.CIR.101.11.1227. PMID 10725278. สืบค้นเมื่อ 11 December 2017.
  6. Mala JG, Rose C (November 2010). "Interactions of heat shock protein 47 with collagen and the stress response: an unconventional chaperone model?". Life Sciences. 87 (19–22): 579–86. doi:10.1016/j.lfs.2010.09.024. PMID 20888348.

แหล่งข้อมูลอื่น

  • Razzaque MS, Taguchi T (October 1999). "The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases". Histology and Histopathology. 14 (4): 1199–212. PMID 10506936.
  • Gettins PG (December 2002). "Serpin structure, mechanism, and function". Chemical Reviews. 102 (12): 4751–804. doi:10.1021/cr010170. PMID 12475206.
  • Clarke EP, Sanwal BD (January 1992). "Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1129 (2): 246–8. doi:10.1016/0167-4781(92)90498-o. PMID 1309665.
  • Ikegawa S, Sudo K, Okui K, Nakamura Y (1995). "Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2)". Cytogenetics and Cell Genetics. 71 (2): 182–6. doi:10.1159/000134103. PMID 7656593.
  • Ikegawa S, Nakamura Y (July 1997). "Structure of the gene encoding human colligin-2 (CBP2)". Gene. 194 (2): 301–3. doi:10.1016/S0378-1119(97)00209-6. PMID 9272875.
  • Bekri S, Adélaïde J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pébusque MJ, Theillet C, Birnbaum D, Gaudray P (1998). "Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma". Cytogenetics and Cell Genetics. 79 (1–2): 125–31. doi:10.1159/000134699. PMID 9533029.
  • Hattori T, Fujisawa T, Sasaki K, Yutani Y, Nakanishi T, Takahashi K, Takigawa M (April 1998). "Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8)". Biochemical and Biophysical Research Communications. 245 (3): 679–83. doi:10.1006/bbrc.1998.8505. PMID 9588174.
  • Nagai N, Tetuya Y, Hosokawa N, Nagata K (February 1999). "The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)". Gene. 227 (2): 241–8. doi:10.1016/S0378-1119(98)00592-7. PMID 10023073.
  • Hebert C, Norris K, Della Coletta R, Reynolds M, Ordóñez J, Sauk JJ (May 1999). "Cell surface colligin/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines". Journal of Cellular Biochemistry. 73 (2): 248–58. doi:10.1002/(SICI)1097-4644(19990501)73:2<248::AID-JCB11>3.0.CO;2-A. PMID 10227388.
  • Koide T, Aso A, Yorihuzi T, Nagata K (September 2000). "Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47". The Journal of Biological Chemistry. 275 (36): 27957–63. doi:10.1074/jbc.M003026200. PMID 10862616.
  • Hattori T, Takahash K, Yutani Y, Fujisawa T, Nakanishi T, Takigawa M (2001). "Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47". Journal of Bone and Mineral Metabolism. 18 (6): 328–34. doi:10.1007/s007740070004. PMID 11052465. S2CID 35696096.
  • Pelletier G, Stefanovsky VY, Faubladier M, Hirschler-Laszkiewicz I, Savard J, Rothblum LI, Côté J, Moss T (November 2000). "Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription". Molecular Cell. 6 (5): 1059–66. doi:10.1016/S1097-2765(00)00104-0. PMID 11106745.
  • Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochemical and Biophysical Research Communications. 280 (2): 535–40. doi:10.1006/bbrc.2000.4149. PMID 11162551.
  • Zhou M, Nekhai S, Bharucha DC, Kumar A, Ge H, Price DH, Egly JM, Brady JN (November 2001). "TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription". The Journal of Biological Chemistry. 276 (48): 44633–40. doi:10.1074/jbc.M107466200. PMID 11572868.
  • Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G (March 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222.
  • Sasaki H, Sato T, Yamauchi N, Okamoto T, Kobayashi D, Iyama S, Kato J, Matsunaga T, Takimoto R, Takayama T, Kogawa K, Watanabe N, Niitsu Y (May 2002). "Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1". Journal of Immunology. 168 (10): 5178–83. doi:10.4049/jimmunol.168.10.5178. PMID 11994473.
  • Razzaque MS, Ahmed AR (March 2002). "Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis". Cytokine. 17 (6): 311–6. doi:10.1006/cyto.2002.1020. PMID 12061838.
  • Sato K, Yomogida K, Wada T, Yorihuzi T, Nishimune Y, Hosokawa N, Nagata K (October 2002). "Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary". The Journal of Biological Chemistry. 277 (40): 37678–84. doi:10.1074/jbc.M205347200. PMID 12145293.
  • Rocnik EF, van der Veer E, Cao H, Hegele RA, Pickering JG (October 2002). "Functional linkage between the endoplasmic reticulum protein Hsp47 and procollagen expression in human vascular smooth muscle cells". The Journal of Biological Chemistry. 277 (41): 38571–8. doi:10.1074/jbc.M206689200. PMID 12163502.
  • ฐานข้อมูลออนไลน์ MEROPS สำหรับเปปทิเดส และสารยับยั้งเปปทิเดส: I04.035
  • HSP47 Heat-Shock Proteins ในหอสมุดแพทยศาสตร์แห่งชาติอเมริกัน สำหรับหัวข้อเนื้อหาทางการแพทย์ (MeSH)


สิงหาคม 08, 2021
ทช, อคโปรต, หร, เซอร, เอช1, งกฤษ, heat, shock, protein, hsp47, หร, serpinh1, เป, นโปรต, นกล, มเซอร, นชน, ดหน, งท, พบในม, ษย, บทบาทสำค, ญในกระบวนการการสร, างคอลลาเจน, กถอดรห, สได, จากย, serpinh1, บนโครโมโซมค, serpinh1identifiersaliasesserpinh1, astp3, cbp1, cbp. hithchxkhoprtin 47 hrux esxrpin exch1 xngkvs Heat shock protein 47 HSP47 hrux SERPINH1 epnoprtinklumesxrpinchnidhnungthiphbinmusy mibthbathsakhyinkrabwnkarkarsrangkhxllaecn thukthxdrhsidcakyin SERPINH1 bnokhromosmkhuthi 11 3 4 SERPINH1IdentifiersAliasesSERPINH1 AsTP3 CBP1 CBP2 HSP47 OI10 PIG14 PPROM RA A47 SERPINH2 gp46 serpin family H member 1External IDsOMIM 600943 HomoloGene 20331 GeneCards SERPINH1Gene location Human Chr Chromosome 11 human 1 Band11q13 5Start75 562 056 bp 1 End75 572 783 bp 1 RNA expression patternMore reference expression dataGene ontologyMolecular function unfolded protein binding collagen binding RNA binding serine type endopeptidase inhibitor activityCellular component isothphlasum membrane raft endoplasmic reticulum lumen exkososmchnidphaynxkesll endoplasmic reticulum Golgi intermediate compartment phaynxkesll rangaehexnodphlasum sarekhluxbesllthimikhxllaecnepnswnprakxbBiological process response to unfolded protein protein maturation chondrocyte development involved in endochondral bone morphogenesis collagen biosynthetic process collagen fibril organization negative regulation of endopeptidase activitySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez871n aEnsemblENSG00000149257n aUniProtP50454n aRefSeq mRNA NM 001207014NM 001235n aRefSeq protein NP 001193943NP 001226n aLocation UCSC Chr 11 75 56 75 57 Mbn aPubMed search 2 n aWikidataView Edit Human enuxha 1 hnathi 2 xntrkiriya 3 xangxing 4 aehlngkhxmulxunhnathi aekikhHSP47 epnsmachikhnunginoprtinmhawngsesxrpin thahnathiybyngkarthangankhxngexnismsirinoprtiexs karaesdngxxkkhxngoprtinchnidnisamarthehniywnaidodykarkratunesllihekidkhwamekhriyddwykhwamrxn heat shock odycaphbkaraesdngxxkkhxng HSP47 inesllthimirangaehexnodphlasum sungesllehlanicasrangaelahlngkhxllaecnchnid I aelachnid II 5 HSP47 caekhluxnthiekhaipyng lumen khxngrangaehexnodphlasumaelaekhacbkbkhxllaecn dngnncungkhadkarnidwa HSP47 epnaechphephxrxnthithahnathiekiywkhxngkbkarddaeplngomelkulkhxngkhxllaecnihmisphaphphrxmthangan xyangirktam inphupwyorkhkhxxkesbrumatxydxacphbkaraesdngxxkkhxng HSP47 idnxykwapkti enuxngcakmikarsrangsarphumitanthantantnexng autoantibody tx HSP47 3 xntrkiriya aekikhHSP47 samarthekidxntrkiriyakbkhxllaecnchnid I II III IV aela V id 6 ladbkrdxamion1020304050MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDELA xalanin C sistixin D krdaexspartik E klutaemt F finilxalanin G iklsin H histhidin I ixosliwsin K ilsin L liwsin M miithoxnin N aexspharacin P ophrlin Q klutamin R xarcinin S sirin T thrioxnin V walin W thripotefn Y ithorsinxangxing aekikh 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000149257 Ensembl May 2017 Human PubMed Reference 3 0 3 1 Entrez Gene SERPINH1 serpin peptidase inhibitor clade H heat shock protein 47 member 1 collagen binding protein 1 Dafforn TR Della M Miller AD December 2001 The molecular interactions of heat shock protein 47 Hsp47 and their implications for collagen biosynthesis The Journal of Biological Chemistry 276 52 49310 9 doi 10 1074 jbc M108896200 PMID 11592970 Williams R Sanders 21 March 2000 Heat Shock Protein 47 A Chaperone for the Fibrous Cap Circulation phasaxngkvs 101 11 1227 1228 doi 10 1161 01 CIR 101 11 1227 PMID 10725278 subkhnemux 11 December 2017 Mala JG Rose C November 2010 Interactions of heat shock protein 47 with collagen and the stress response an unconventional chaperone model Life Sciences 87 19 22 579 86 doi 10 1016 j lfs 2010 09 024 PMID 20888348 aehlngkhxmulxun aekikhRazzaque MS Taguchi T October 1999 The possible role of colligin HSP47 a collagen binding protein in the pathogenesis of human and experimental fibrotic diseases Histology and Histopathology 14 4 1199 212 PMID 10506936 Gettins PG December 2002 Serpin structure mechanism and function Chemical Reviews 102 12 4751 804 doi 10 1021 cr010170 PMID 12475206 Clarke EP Sanwal BD January 1992 Cloning of a human collagen binding protein and its homology with rat gp46 chick hsp47 and mouse J6 proteins Biochimica et Biophysica Acta BBA Gene Structure and Expression 1129 2 246 8 doi 10 1016 0167 4781 92 90498 o PMID 1309665 Ikegawa S Sudo K Okui K Nakamura Y 1995 Isolation characterization and chromosomal assignment of human colligin 2 gene CBP2 Cytogenetics and Cell Genetics 71 2 182 6 doi 10 1159 000134103 PMID 7656593 Ikegawa S Nakamura Y July 1997 Structure of the gene encoding human colligin 2 CBP2 Gene 194 2 301 3 doi 10 1016 S0378 1119 97 00209 6 PMID 9272875 Bekri S Adelaide J Merscher S Grosgeorge J Caroli Bosc F Perucca Lostanlen D Kelley PM Pebusque MJ Theillet C Birnbaum D Gaudray P 1998 Detailed map of a region commonly amplified at 11q13 gt q14 in human breast carcinoma Cytogenetics and Cell Genetics 79 1 2 125 31 doi 10 1159 000134699 PMID 9533029 Hattori T Fujisawa T Sasaki K Yutani Y Nakanishi T Takahashi K Takigawa M April 1998 Isolation and characterization of a rheumatoid arthritis specific antigen RA A47 from a human chondrocytic cell line HCS 2 8 Biochemical and Biophysical Research Communications 245 3 679 83 doi 10 1006 bbrc 1998 8505 PMID 9588174 Nagai N Tetuya Y Hosokawa N Nagata K February 1999 The human genome has only one functional hsp47 gene CBP2 and a pseudogene pshsp47 Gene 227 2 241 8 doi 10 1016 S0378 1119 98 00592 7 PMID 10023073 Hebert C Norris K Della Coletta R Reynolds M Ordonez J Sauk JJ May 1999 Cell surface colligin Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines Journal of Cellular Biochemistry 73 2 248 58 doi 10 1002 SICI 1097 4644 19990501 73 2 lt 248 AID JCB11 gt 3 0 CO 2 A PMID 10227388 Koide T Aso A Yorihuzi T Nagata K September 2000 Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47 The Journal of Biological Chemistry 275 36 27957 63 doi 10 1074 jbc M003026200 PMID 10862616 Hattori T Takahash K Yutani Y Fujisawa T Nakanishi T Takigawa M 2001 Rheumatoid arthritis related antigen 47kDa RA A47 is a product of colligin 2 and acts as a human HSP47 Journal of Bone and Mineral Metabolism 18 6 328 34 doi 10 1007 s007740070004 PMID 11052465 S2CID 35696096 Pelletier G Stefanovsky VY Faubladier M Hirschler Laszkiewicz I Savard J Rothblum LI Cote J Moss T November 2000 Competitive recruitment of CBP and Rb HDAC regulates UBF acetylation and ribosomal transcription Molecular Cell 6 5 1059 66 doi 10 1016 S1097 2765 00 00104 0 PMID 11106745 Matsuda M Koide T Yorihuzi T Hosokawa N Nagata K January 2001 Molecular cloning of a novel ubiquitin like protein UBIN that binds to ER targeting signal sequences Biochemical and Biophysical Research Communications 280 2 535 40 doi 10 1006 bbrc 2000 4149 PMID 11162551 Zhou M Nekhai S Bharucha DC Kumar A Ge H Price DH Egly JM Brady JN November 2001 TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription The Journal of Biological Chemistry 276 48 44633 40 doi 10 1074 jbc M107466200 PMID 11572868 Song CZ Keller K Murata K Asano H Stamatoyannopoulos G March 2002 Functional interaction between coactivators CBP p300 PCAF and transcription factor FKLF2 The Journal of Biological Chemistry 277 9 7029 36 doi 10 1074 jbc M108826200 PMC 2808425 PMID 11748222 Sasaki H Sato T Yamauchi N Okamoto T Kobayashi D Iyama S Kato J Matsunaga T Takimoto R Takayama T Kogawa K Watanabe N Niitsu Y May 2002 Induction of heat shock protein 47 synthesis by TGF beta and IL 1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1 Journal of Immunology 168 10 5178 83 doi 10 4049 jimmunol 168 10 5178 PMID 11994473 Razzaque MS Ahmed AR March 2002 Collagens collagen binding heat shock protein 47 and transforming growth factor beta 1 are induced in cicatricial pemphigoid possible role s in dermal fibrosis Cytokine 17 6 311 6 doi 10 1006 cyto 2002 1020 PMID 12061838 Sato K Yomogida K Wada T Yorihuzi T Nishimune Y Hosokawa N Nagata K October 2002 Type XXVI collagen a new member of the collagen family is specifically expressed in the testis and ovary The Journal of Biological Chemistry 277 40 37678 84 doi 10 1074 jbc M205347200 PMID 12145293 Rocnik EF van der Veer E Cao H Hegele RA Pickering JG October 2002 Functional linkage between the endoplasmic reticulum protein Hsp47 and procollagen expression in human vascular smooth muscle cells The Journal of Biological Chemistry 277 41 38571 8 doi 10 1074 jbc M206689200 PMID 12163502 thankhxmulxxniln MEROPS sahrbeppthieds aelasarybyngeppthieds I04 035 HSP47 Heat Shock Proteins inhxsmudaephthysastraehngchatixemrikn sahrbhwkhxenuxhathangkaraephthy MeSH bthkhwamniekiywkhxngkbyinbnokhromosmkhuthi 11 aelaepnbthkhwamthikalngrxephimetimkhxmul khunsamarthchwyephimetimkhxmulinswnniidekhathungcak https th wikipedia org w index php title hithchxkhoprtin 47 amp oldid 9112629, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,

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