↑ GRCh38: Ensembl release 89: ENSG00000167531 - Ensembl, May 2017
"Human PubMed Reference:".
↑ "Entrez Gene: LALBA lactalbumin, alpha-".
Hall L, Davies MS, Craig RK (January 1981). "The construction, identification and characterisation of plasmids containing human alpha-lactalbumin cDNA sequences". Nucleic Acids Res. 9 (1): 65–84. doi:10.1093/nar/9.1.65. PMC326669. PMID 6163135.
Hall L, Emery DC, Davies MS, Parker D, Craig RK (March 1987). "Organization and sequence of the human alpha-lactalbumin gene". Biochem. J. 242 (3): 735–42. PMC1147772. PMID 2954544.
↑ Qasba PK, Kumar S (1997). "Molecular divergence of lysozymes and alpha-lactalbumin". Crit. Rev. Biochem. Mol. Biol. 32 (4): 255–306. doi:10.3109/10409239709082574. PMID 9307874.
↑ Svensson M, Håkansson A, Mossberg AK, Linse A, and Svanborg C (2000). "Conversion of alpha-lactalbumin to a protein inducing apoptosis". Proc Natl Acad Sci USA. 97 (8): 4221–6. doi:10.1073/pnas.97.8.4221. PMC18203. PMID 10760289.
↑ Kleinberg JL, Todd J, Babitsky G (1983). "Inhibition by estradiol of the lactogenic effect of prolactin in primate mammary tissue: reversal by antiestrogens LY 156758 and tamoxifen". PNAS. 80 (13): 4144–4148. doi:10.1073/pnas.80.13.4144. PMC394217. PMID 6575400.
Ramakrishnan, Boopathy; Boeggeman, Elizabeth; Qasba, Pradman K. (2002-03-15). "Beta-1,4-galactosyltransferase and lactose synthase: molecular mechanical devices". Biochemical and Biophysical Research Communications. 291 (5): 1113–1118. doi:10.1006/bbrc.2002.6506. ISSN 0006-291X. PMID 11883930.
Bu, Z.; Cook, J.; Callaway, D. J. E. (2001). "Dynamic regimes and correlated structural dynamics in native and denatured alpha-lactalbumin". J. Mol. Biol. 312 (4): 865–873. doi:10.1006/jmbi.2001.5006. PMID 11575938.
Acharya KR, Stuart DI, Walker NP, Lewis M, Phillips DC (1989). "Refined structure of baboon alpha-lactalbumin at 1.7 A resolution. Comparison with C-type lysozyme". J. Mol. Biol. 208 (1): 99–127. doi:10.1016/0022-2836(89)90091-0. PMID 2769757.
Prager EM, Wilson AC (1988). "Ancient origin of lactalbumin from lysozyme: analysis of DNA and amino acid sequences". J. Mol. Evol. 27 (4): 326–35. doi:10.1007/BF02101195. PMID 3146643. S2CID 10039589.
แหล่งข้อมูลอื่น
Heine WE, Klein PD, Reeds PJ (1991). "The importance of alpha-lactalbumin in infant nutrition". J. Nutr. 121 (3): 277–83. PMID 2002399.
Permyakov EA, Berliner LJ (2000). "alpha-Lactalbumin: structure and function". FEBS Lett. 473 (3): 269–74. doi:10.1016/S0014-5793(00)01546-5. PMID 10818224.
Hall L, Emery DC, Davies MS, และคณะ (1987). "Organization and sequence of the human alpha-lactalbumin gene". Biochem. J. 242 (3): 735–42. PMC1147772. PMID 2954544.
Davies MS, West LF, Davis MB, และคณะ (1987). "The gene for human alpha-lactalbumin is assigned to chromosome 12q13". Ann. Hum. Genet. 51 (Pt 3): 183–8. doi:10.1111/j.1469-1809.1987.tb00869.x. PMID 3479943.
Findlay JB, Brew K (1972). "The complete amino-acid sequence of human -lactalbumin". Eur. J. Biochem. 27 (1): 65–86. doi:10.1111/j.1432-1033.1972.tb01812.x. PMID 5049057.
Hall L, Craig RK, Edbrooke MR, Campbell PN (1982). "Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene". Nucleic Acids Res. 10 (11): 3503–3515. doi:10.1093/nar/10.11.3503. PMC320727. PMID 6285305.
Håkansson A, Zhivotovsky B, Orrenius S, และคณะ (1995). "Apoptosis induced by a human milk protein". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 8064–8068. doi:10.1073/pnas.92.17.8064. PMC41287. PMID 7644538.
Stacey A, Schnieke A, Kerr M, และคณะ (1995). "Lactation is disrupted by alpha-lactalbumin deficiency and can be restored by human alpha-lactalbumin gene replacement in mice". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2835–2839. doi:10.1073/pnas.92.7.2835. PMC42313. PMID 7708733.
Fujiwara Y, Miwa M, Takahashi R, และคณะ (1997). "Position-independent and high-level expression of human alpha-lactalbumin in the milk of transgenic rats carrying a 210-kb YAC DNA". Mol. Reprod. Dev. 47 (2): 157–63. doi:10.1002/(SICI)1098-2795(199706)47:2<157::AID-MRD5>3.0.CO;2-L. PMID 9136116.
Lindner RA, Kapur A, Carver JA (1997). "The interaction of the molecular chaperone, alpha-crystallin, with molten globule states of bovine alpha-lactalbumin". J. Biol. Chem. 272 (44): 27722–9. doi:10.1074/jbc.272.44.27722. PMID 9346914.
Giuffrida MG, Cavaletto M, Giunta C, และคณะ (1998). "The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin". J. Protein Chem. 16 (8): 747–53. doi:10.1023/A:1026359715821. PMID 9365923.
Chandra N, Brew K, Acharya KR (1998). "Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin". Biochemistry. 37 (14): 4767–4772. doi:10.1021/bi973000t. PMID 9537992.
Håkansson A, Andréasson J, Zhivotovsky B, และคณะ (1999). "Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei". Exp. Cell Res. 246 (2): 451–60. doi:10.1006/excr.1998.4265. PMID 9925761.
Svensson M, Sabharwal H, Håkansson A, และคณะ (1999). "Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells". J. Biol. Chem. 274 (10): 6388–6396. doi:10.1074/jbc.274.10.6388. PMID 10037730.
Harata K, Abe Y, Muraki M (1999). "Crystallographic evaluation of internal motion of human alpha-lactalbumin refined by full-matrix least-squares method". J. Mol. Biol. 287 (2): 347–58. doi:10.1006/jmbi.1999.2598. PMID 10080897.
Last AM, Schulman BA, Robinson CV, Redfield C (2001). "Probing subtle differences in the hydrogen exchange behavior of variants of the human alpha-lactalbumin molten globule using mass spectrometry". J. Mol. Biol. 311 (4): 909–19. doi:10.1006/jmbi.2001.4911. PMID 11518539.
Bai P, Peng Z (2001). "Cooperative folding of the isolated alpha-helical domain of hen egg-white lysozyme". J. Mol. Biol. 314 (2): 321–9. doi:10.1006/jmbi.2001.5122. PMID 11718563.
Andrews P (1970). "Purification of lactose synthetase a protein from human milk and demonstration of its interaction with alpha-lactalbumin". FEBS Letters. 9 (5): 297–300. doi:10.1016/0014-5793(70)80382-9. PMID 11947697.
แอลฟา, แลคต, ลบ, งกฤษ, alpha, lactalbumin, หร, lalba, เป, นโปรต, นท, พบในมน, ษย, กถอดรห, สได, โดยย, lalba, บนโครโมโซมค, หน, าท, สำค, ญในกระบวนการสร, างน, ำตาลแลคโตสในน, ำนมของส, ตว, เล, ยงล, กด, วยนม, และอาจช, วยลดอ, การณ, การเก, ดมะเร, งในเด, กท, ทานนมแม, ได,. aexlfa aelkhtlbumin xngkvs Alpha lactalbumin hrux LALBA epnoprtinthiphbinmnusy thukthxdrhsidodyyin LALBA bnokhromosmkhuthi 12 3 4 5 mihnathisakhyinkrabwnkarsrangnatalaelkhotsinnanmkhxngstweliynglukdwynm 6 aelaxacchwyldxubtikarnkarekidmaernginedkthithannmaemid 7 LALBAAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes4L41 1A4V 1B9O 1CB3 1HML 3B0I 3B0OIdentifiersAliasesLALBA entrez 3906 LYZG lactalbumin alphaExternal IDsOMIM 149750 HomoloGene 1720 GeneCards LALBAGene location Human Chr Chromosome 12 human 1 Band12q13 11Start48 567 684 bp 1 End48 570 066 bp 1 RNA expression patternMore reference expression dataGene ontologyMolecular function calcium ion binding metal ion binding lactose synthase activity lysozyme activityCellular component extracellular region Golgi lumen Golgi membrane phaynxkesllBiological process xaphxphothsis karthayoxnsyyan defense response to bacterium cell cell signaling lactose biosynthetic process cell wall macromolecule catabolic process GO 0051636 defense response to Gram negative bacterium GO 0051637 defense response to Gram positive bacteriumSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez3906n aEnsemblENSG00000167531n aUniProtP00709n aRefSeq mRNA NM 002289NM 001384350n aRefSeq protein NP 002280n aLocation UCSC Chr 12 48 57 48 57 Mbn aPubMed search 2 n aWikidataView Edit Human enuxha 1 bthbathaelahnathi 2 khunsmbtithangkayphaph 3 wiwthnakar 4 xangxing 5 aehlngkhxmulxunbthbathaelahnathi aekikhaexlfa aelkhtlbuminepnoprtinthikhwbkhumkrabwnkarsrangnatalaelkhotsinnanmkhxngstweliynglukdwynmekuxbthukspichis 6 inlingiphremt karhlngkhxnghxromnopraelkhtincakratunihmikaraesdngxxkkhxngyin LALBA thisrangaexlfa aelkhtlbumin ephimmakkhun 8 aexlfa aelkhtlbuminthiephimkhunni cachwyephimkhwamsamarthinkarekhacbkbsbsetrtkhxngexnismexnxaesthilaelkhotsaminsineths aelasngphlihekidkarsrangnatalaelkhotsephimmakkhuninthisud 8 9 inkrabwnkhangtn aexlfa aelkhtlbumincathahnathisrangehthethxoridemxrkhxngexnismaelkhotssineths LS heterodimer aela B4GALT1 b 1 4 galactosyltransferase casrangsarprakxbinkarerngptikiriya oprtinthng 2 chnidthiekidkhunnicathaih LS samarthsrangnatalaelkhotsidodykarthayoxnswnhnung moiety khxngomelkulkaaelkhotsekhathaptikiriyakbkluokhs sungemuxaexlfa aelkhtlbuminekidsarprakxbesingsxnkb B4GALT1 cathaihexnismdngklawmikhwamsamarthinkarekhacbkbkluokhsidmakkwa 1 000 etha aelayngsngphlybyngkarekidphxliemxrkhxngkaaelkhotsiddwy 3 enuxngcakaexlfa aelkhtlbumincdepnoprtinthimikhnadihy multimeric protein insphawapkticungsamarthekhacbkbixxxnkhxngaekhlesiymaelasngkasiidxyangaekhngaerng aetemuxxyuinsphaphthiepnkrd echn inkraephaaxahar ixxxnkhxngaekhlesiymcathukpldplxyxxkmaaelwipkratunihekidkarhlngexnismileps ephuxyxyitrkliesxirdthixyuinnanm nxkcakni karphbaeprkhxngaexlfa aelkhtlbuminkhxngmnusyinsphaphaewdlxmdngklaw thieriykwa HAMLET xacehniywnaihekidxaphxphothsiskhxngenuxngxkinthangedinxaharkhxngedkthikinnmaemid 3 7 dngnn aexlfa aelkhtlbuminxacthahnathithangchiwphaphidaetktangknxyangmakkhunxyukbsthanakarphbkhxngomelkulaelasphaphaewdlxminrangkay aelasnnisthanidwa HAMLET xacsamarthchwyldxubtikarnkhxngmaernginedkthikinnmaemidodykarkacdesllenuxngxkxxkcaklais 7 10 khunsmbtithangkayphaph aekikhokhrngsrangkhxng xlfa aelktlbumin epnthiruckkndiaelaprakxbdwykrdxamion 123 hnwyaelasaphanidslifd 4 tw nahnkomelkulkhux 14178 Da aelacudixosxielkthrikxyurahwang 4 2 thung 4 5 khwamaetktangkhxngokhrngsranghlkxyanghnungkbkhxngebta aelkhotoklbulinkhux immiklumithxxlxisraid thisamarthichepncuderimtnkhxngptikiriyaokhwaelntmwlrwm epnphlih xlfa aelktlbuminbrisuththicaimkxtwepneclemuxmikaraeplngsphaph aelakarthaihepnkrdwiwthnakar aekikhkarepriybethiybladbkhxng aexlfa aelktlbumin aesdngihehnthungkhwamkhlaykhlungknxyangmakkbilosism odyechphaa Ca2 binding c lysozyme 11 dngnnprawtiwiwthnakarthikhadiwkkhuxkarthasaenakhxngyin c lysozyme tammadwykarklayphnthu 6 yinniekidkhunkxninbrrphburusrwmknkhxngstweliynglukdwynmaelank sungxacmitnkaenidxyuthipraman 300 lanpi 12 xangxing aekikh 1 0 1 1 1 2 GRCh38 Ensembl release 89 ENSG00000167531 Ensembl May 2017 Human PubMed Reference 3 0 3 1 3 2 Entrez Gene LALBA lactalbumin alpha Hall L Davies MS Craig RK January 1981 The construction identification and characterisation of plasmids containing human alpha lactalbumin cDNA sequences Nucleic Acids Res 9 1 65 84 doi 10 1093 nar 9 1 65 PMC 326669 PMID 6163135 Hall L Emery DC Davies MS Parker D Craig RK March 1987 Organization and sequence of the human alpha lactalbumin gene Biochem J 242 3 735 42 PMC 1147772 PMID 2954544 6 0 6 1 6 2 Qasba PK Kumar S 1997 Molecular divergence of lysozymes and alpha lactalbumin Crit Rev Biochem Mol Biol 32 4 255 306 doi 10 3109 10409239709082574 PMID 9307874 7 0 7 1 7 2 Svensson M Hakansson A Mossberg AK Linse A and Svanborg C 2000 Conversion of alpha lactalbumin to a protein inducing apoptosis Proc Natl Acad Sci USA 97 8 4221 6 doi 10 1073 pnas 97 8 4221 PMC 18203 PMID 10760289 8 0 8 1 Kleinberg JL Todd J Babitsky G 1983 Inhibition by estradiol of the lactogenic effect of prolactin in primate mammary tissue reversal by antiestrogens LY 156758 and tamoxifen PNAS 80 13 4144 4148 doi 10 1073 pnas 80 13 4144 PMC 394217 PMID 6575400 Ramakrishnan Boopathy Boeggeman Elizabeth Qasba Pradman K 2002 03 15 Beta 1 4 galactosyltransferase and lactose synthase molecular mechanical devices Biochemical and Biophysical Research Communications 291 5 1113 1118 doi 10 1006 bbrc 2002 6506 ISSN 0006 291X PMID 11883930 Bu Z Cook J Callaway D J E 2001 Dynamic regimes and correlated structural dynamics in native and denatured alpha lactalbumin J Mol Biol 312 4 865 873 doi 10 1006 jmbi 2001 5006 PMID 11575938 Acharya KR Stuart DI Walker NP Lewis M Phillips DC 1989 Refined structure of baboon alpha lactalbumin at 1 7 A resolution Comparison with C type lysozyme J Mol Biol 208 1 99 127 doi 10 1016 0022 2836 89 90091 0 PMID 2769757 Prager EM Wilson AC 1988 Ancient origin of lactalbumin from lysozyme analysis of DNA and amino acid sequences J Mol Evol 27 4 326 35 doi 10 1007 BF02101195 PMID 3146643 S2CID 10039589 aehlngkhxmulxun aekikhHeine WE Klein PD Reeds PJ 1991 The importance of alpha lactalbumin in infant nutrition J Nutr 121 3 277 83 PMID 2002399 Permyakov EA Berliner LJ 2000 alpha Lactalbumin structure and function FEBS Lett 473 3 269 74 doi 10 1016 S0014 5793 00 01546 5 PMID 10818224 Hall L Emery DC Davies MS aelakhna 1987 Organization and sequence of the human alpha lactalbumin gene Biochem J 242 3 735 42 PMC 1147772 PMID 2954544 Davies MS West LF Davis MB aelakhna 1987 The gene for human alpha lactalbumin is assigned to chromosome 12q13 Ann Hum Genet 51 Pt 3 183 8 doi 10 1111 j 1469 1809 1987 tb00869 x PMID 3479943 Findlay JB Brew K 1972 The complete amino acid sequence of human lactalbumin Eur J Biochem 27 1 65 86 doi 10 1111 j 1432 1033 1972 tb01812 x PMID 5049057 Hall L Craig RK Edbrooke MR Campbell PN 1982 Comparison of the nucleotide sequence of cloned human and guinea pig pre alpha lactalbumin cDNA with that of chick pre lysozyme cDNA suggests evolution from a common ancestral gene Nucleic Acids Res 10 11 3503 3515 doi 10 1093 nar 10 11 3503 PMC 320727 PMID 6285305 Hakansson A Zhivotovsky B Orrenius S aelakhna 1995 Apoptosis induced by a human milk protein Proc Natl Acad Sci U S A 92 17 8064 8068 doi 10 1073 pnas 92 17 8064 PMC 41287 PMID 7644538 Stacey A Schnieke A Kerr M aelakhna 1995 Lactation is disrupted by alpha lactalbumin deficiency and can be restored by human alpha lactalbumin gene replacement in mice Proc Natl Acad Sci U S A 92 7 2835 2839 doi 10 1073 pnas 92 7 2835 PMC 42313 PMID 7708733 Fujiwara Y Miwa M Takahashi R aelakhna 1997 Position independent and high level expression of human alpha lactalbumin in the milk of transgenic rats carrying a 210 kb YAC DNA Mol Reprod Dev 47 2 157 63 doi 10 1002 SICI 1098 2795 199706 47 2 lt 157 AID MRD5 gt 3 0 CO 2 L PMID 9136116 Lindner RA Kapur A Carver JA 1997 The interaction of the molecular chaperone alpha crystallin with molten globule states of bovine alpha lactalbumin J Biol Chem 272 44 27722 9 doi 10 1074 jbc 272 44 27722 PMID 9346914 Giuffrida MG Cavaletto M Giunta C aelakhna 1998 The unusual amino acid triplet Asn Ile Cys is a glycosylation consensus site in human alpha lactalbumin J Protein Chem 16 8 747 53 doi 10 1023 A 1026359715821 PMID 9365923 Chandra N Brew K Acharya KR 1998 Structural evidence for the presence of a secondary calcium binding site in human alpha lactalbumin Biochemistry 37 14 4767 4772 doi 10 1021 bi973000t PMID 9537992 Hakansson A Andreasson J Zhivotovsky B aelakhna 1999 Multimeric alpha lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei Exp Cell Res 246 2 451 60 doi 10 1006 excr 1998 4265 PMID 9925761 Svensson M Sabharwal H Hakansson A aelakhna 1999 Molecular characterization of alpha lactalbumin folding variants that induce apoptosis in tumor cells J Biol Chem 274 10 6388 6396 doi 10 1074 jbc 274 10 6388 PMID 10037730 Harata K Abe Y Muraki M 1999 Crystallographic evaluation of internal motion of human alpha lactalbumin refined by full matrix least squares method J Mol Biol 287 2 347 58 doi 10 1006 jmbi 1999 2598 PMID 10080897 Last AM Schulman BA Robinson CV Redfield C 2001 Probing subtle differences in the hydrogen exchange behavior of variants of the human alpha lactalbumin molten globule using mass spectrometry J Mol Biol 311 4 909 19 doi 10 1006 jmbi 2001 4911 PMID 11518539 Bai P Peng Z 2001 Cooperative folding of the isolated alpha helical domain of hen egg white lysozyme J Mol Biol 314 2 321 9 doi 10 1006 jmbi 2001 5122 PMID 11718563 Andrews P 1970 Purification of lactose synthetase a protein from human milk and demonstration of its interaction with alpha lactalbumin FEBS Letters 9 5 297 300 doi 10 1016 0014 5793 70 80382 9 PMID 11947697 alpha Lactalbumin inhxsmudaephthysastraehngchatixemrikn sahrbhwkhxenuxhathangkaraephthy MeSH taaehnngcionm LALBA khxngmnusy aelahnaephcaesdngkhxmulekiywkbyin LALBA in UCSC Genome Browser ekhathungcak https th wikipedia org w index php title aexlfa aelkhtlbumin amp oldid 9263155, wikipedia, วิกิ หนังสือ, หนังสือ, ห้องสมุด,
